Ovarian infertility and subfertility presenting with premature ovarian insufficiency (POI) and
diminished ovarian reserve are major issues facing the developed world due to the trend of …

Mitochondria are the most abundant organelles in mammalian oocytes and early embryos.
Mitochondrial DNA (mtDNA) mutations, including the common deletion, have been found in …

Polycystic ovary syndrome (PCOS) is a complex, but relatively common endocrine disorder
associated with chronic anovulation, hyperandrogenism, and micro-polycystic ovaries. In …

Premature ovarian insufficiency (POI) is a condition that arises from dysfunction or early
depletion of the ovarian follicle pool accompanied by an earlier-than-normal loss of fertility in …

STUDY QUESTION What is the prevalence of somatic chromosomal instability among
women with idiopathic primary ovarian insufficiency (POI)? SUMMARY ANSWER A subset …

Objective: To compare the level of mitochondrial ATPase 6 gene expression in unfertilized
oocytes and cleavage-stage embryos. Design: Reverse transcription polymerase chain …

Mitochondria play vital roles in oocyte functions and they are critical indicators of oocyte
quality which is important for fertilization and development into viable offspring. Quality …

The objective of this work was to determine the role of mitochondria in the loss of oocyte
quality with maternal aging. Our results show that mitochondrial DNA (mtDNA) copy number …

Purpose To investigate the potential etiologies of premature ovarian insufficiency (POI) and
diminished ovarian reserve (DOR). Methods Fourteen women with sporadic POI and 6 …

The role of mitochondria in the establishment of developmental competence for the
preimplantation mammalian embryo is an area of growing interest for researchers …