HIV-1 regulator of virion expression (Rev) protein binds to an RNA stem-loop structure located within the Rev response element region

S Heaphy, C Dingwall, I Ernberg, MJ Gait, SM Green… - Cell, 1990 - cell.com
HIV-1 Rev protein, purified from E. coli, binds specifically to an RNA transcript containing the
223 nucleotide long Rev response element (RRE) sequence. Rev binds to RRE in vitro with …

Characterization of HIV-1 REV protein: binding stoichiometry and minimal RNA substrate

KS Cook, GJ Fisk, J Hauber, N Usman… - Nucleic acids …, 1991 - academic.oup.com
The HIV-1 REV protein binds to the stem II region of the REV-responsive element (RNA).
Studies to further define the RNA sequence and structure specifically bound by REV protein …

Human immunodeficiency virus rev protein recognizes a target sequence in rev-responsive element RNA within the context of RNA secondary structure

SM Holland, N Ahmad, RK Maitra, P Wingfield… - Journal of …, 1990 - Am Soc Microbiol
Human immunodeficiency virus type 1 Rev protein modulates the distribution of viral mRNAs
from the nucleus to the cytoplasm by interaction with a highly structured viral RNA sequence …

Identification of a high-affinity RNA-binding site for the human immunodeficiency virus type 1 Rev protein.

LS Tiley, MH Malim, HK Tewary… - Proceedings of the …, 1992 - National Acad Sciences
Expression of the structural proteins of human immunodeficiency virus type 1 requires the
direct interaction of multiple copies of the viral Rev protein with its highly structured RNA …

HIV-1 structural gene expression requires binding of the Rev trans-activator to its RNA target sequence

MH Malim, LS Tiley, DF McCarn, JR Rusche, J Hauber… - Cell, 1990 - cell.com
Expression of human immunodeficiency virus type 1 structural proteins requires both the
viral Rev fransactivator and its &-acting RNA target sequence, the Rev response element …

Specific binding of a basic peptide from HIV‐1 Rev.

J Kjems, BJ Calnan, AD Frankel, PA Sharp - The EMBO journal, 1992 - embopress.org
Human immunodeficiency virus type I (HIV‐1) encodes a regulatory protein, Rev, which is
required for cytoplasmic expression of incompletely spliced viral mRNA. Rev activity is …

Functional mapping of the human immunodeficiency virus type 1 Rev RNA binding domain: new insights into the domain structure of Rev and Rex

E Böhnlein, J Berger, J Hauber - Journal of virology, 1991 - Am Soc Microbiol
Expression of human immunodeficiency virus type 1 (HIV-1) structural proteins requires the
direct interaction of the viral trans-activator protein Rev with its cis-acting RNA sequence …

A molecular rheostat: Co-operative rev binding to stem I of the Rev-response element modulates human immunodeficiency virus type-1 late gene expression

DA Mann, I Mikaélian, RW Zemmel, SM Green… - Journal of molecular …, 1994 - Elsevier
The complete biologically active human immunodeficiency virus type-1 (HIV-1) rev-response
element (RRE) RNA is 351 nucleotides (nt) in length, and includes an extra 58 nt on the 5 …

Biochemical characterization of binding of multiple HIV-1 Rev monomeric proteins to the Rev responsive element

TJ Daly, RC Doten, P Rennert, M Auer, H Jaksche… - Biochemistry, 1993 - ACS Publications
Revised Manuscript Received July 22, 19939 abstract: Recombinant HIV-1 Rev protein was
overexpressed in Escherichia coli using translational coupling to the/3-glucuronidase gene …

HIV-1 Rev regulation involves recognition of non-Watson-Crick base pairs in viral RNA

DP Bartel, ML Zapp, MR Green, JW Szostak - Cell, 1991 - cell.com
We have used an iterative in vitro genetic selection to identify the important structural
features of the viral RNA element bound by the Rev protein of human immunodeficiency …