Identification of the appropriate dose metric for pulmonary inflammation of silver nanoparticles in an inhalation toxicity study

HM Braakhuis, FR Cassee, PHB Fokkens… - …, 2016 - Taylor & Francis
A number of studies have shown that induction of pulmonary toxicity by nanoparticles of the
same chemical composition depends on particle size, which is likely in part due to …

Particle size dependent deposition and pulmonary inflammation after short-term inhalation of silver nanoparticles

HM Braakhuis, I Gosens, P Krystek, JAF Boere… - Particle and fibre …, 2014 - Springer
Background Although silver nanoparticles are currently used in more than 400 consumer
products, it is not clear to what extent they induce adverse effects after inhalation during …

Simple in vitro models can predict pulmonary toxicity of silver nanoparticles

HM Braakhuis, C Giannakou, WJGM Peijnenburg… - …, 2016 - Taylor & Francis
To study the effects of nanomaterials after inhalation, a large number of in vitro lung models
have been reported in literature. Although the in vitro models contribute to the reduction of …

Toxicity of silver nanoparticles at the air‐liquid interface

AL Holder, LC Marr - BioMed research international, 2013 - Wiley Online Library
Silver nanoparticles are one of the most prevalent nanomaterials in consumer products.
Some of these products are likely to be aerosolized, making silver nanoparticles a high …

Nanosilver induces minimal lung toxicity or inflammation in a subacute murine inhalation model

LV Stebounova, A Adamcakova-Dodd, JS Kim… - Particle and fibre …, 2011 - Springer
Background There is increasing interest in the environmental and health consequences of
silver nanoparticles as the use of this material becomes widespread. Although human …

[HTML][HTML] Mode of silver clearance following 28-day inhalation exposure to silver nanoparticles determined from lung burden assessment including post-exposure …

MS Jo, JK Kim, Y Kim, HP Kim, HS Kim, K Ahn… - Archives of …, 2020 - Springer
Recently revised OECD inhalation toxicity testing guidelines require measurements of lung
burden immediately after and for periods following exposure for nanomaterials. Lung burden …

Acute inhalation toxicity of silver nanoparticles

JH Sung, JH Ji, KS Song, JH Lee… - Toxicology and …, 2011 - journals.sagepub.com
The acute inhalation toxicity of silver nanoparticles was studied in Sprague-Dawley rats.
Seven-week-old rats, weighing approximately 218 g (males) and 153 g (females), were …

Pulmonary toxicity of instilled silver nanoparticles: influence of size, coating and rat strain

J Seiffert, F Hussain, C Wiegman, F Li, L Bey, W Baker… - PloS one, 2015 - journals.plos.org
Particle size and surface chemistry are potential determinants of silver nanoparticle (AgNP)
respiratory toxicity that may also depend on the lung inflammatory state. We compared the …

Subchronic inhalation toxicity of silver nanoparticles

JH Sung, JH Ji, JD Park, JU Yoon, DS Kim… - Toxicological …, 2009 - academic.oup.com
The subchronic inhalation toxicity of silver nanoparticles was studied in Sprague-Dawley
rats. Eight-week-old rats, weighing approximately 253.2 g (males) and 162.6 g (females) …

Recovery from silver-nanoparticle-exposure-induced lung inflammation and lung function changes in Sprague Dawley rats

KS Song, JH Sung, JH Ji, JH Lee, JS Lee, HR Ryu… - …, 2013 - Taylor & Francis
In a previous study, the lung function, as indicated by the tidal volume, minute volume, and
peak inspiration flow, decreased during 90 days of exposure to silver nanoparticles and was …