We have previously shown that using agonist affinity at recombinant receptors selectively
expressed in clonal cells as the dependent variable in three-dimensional quantitative …

Agonist affinity changes dramatically as a result of serine to alanine mutations (S193A,
S194A, and S197A) within the fifth transmembrane region of D2 dopamine receptors and …

Determination of quantitative structure− activity relationships (QSAR) for affinity at particular
dopamine (DA) receptors has become an even greater priority with the cloning of five DA …

Subtype selective dopamine receptor ligands have long been sought after as therapeutic
and/or imaging agents for the treatment and monitoring of neurologic disorders. We report …

A combined modeling approach was used to identify structural factors that underlie the
structure–activity relationships (SARs) of full dopamine D2 receptor agonists and structurally …

Computer-aided conformational analysis was used to characterize the agonist
pharmacophore for D1 dopamine receptor recognition and activation. Dihydrexidine (DHX) …

This study is focused on the identification of structural features that determine the selectivity
of dopamine receptor agonists toward D1 and D2 receptors. Selective pharmacophore …

The aim of this study was to use a combined structure and pharmacophore modeling
approach to extract information regarding dopamine D1 receptor agonism and D1/D2 …

We applied a novel molecular descriptor, three‐dimensional biologically relevant spectrum
(BRS‐3D), in subtype selectivity prediction of dopamine receptor (DR) ligands. BRS‐3D is a …

A series of 37 benzolactam derivatives were synthesized, and their respective affinities for
the dopamine D2 and D3 receptors evaluated. The relationships between structures and …