Experimental autoimmune encephalomyelitis (EAE) is a Tcell-mediated autoimmune
disease of the CNS that is widely used as an animal model of multiple sclerosis. In this …

Intracerebral infection of mice with mouse hepatitis virus (MHV) results in an acute
encephalomyelitis followed by a chronic demyelinating disease with clinical and histological …

The chemokine receptor CXCR3 promotes the trafficking of activated T and NK cells in
response to three ligands, CXCL9, CXCL10, and CXCL11. Although these chemokines are …

Chemokines regulate lymphocyte trafficking under physiologic and pathologic conditions. In
this study, we have investigated the role of CXCR3 and CXCR4 in the activation of T …

Chemokine CXCL12 (C‐X‐C motif chemokine ligand 12) restricts immune cell invasion of
the central nervous system (CNS) and limits neuroinflammation in experimental autoimmune …

The inflammatory response in the CNS begins with the movement of leukocytes across the
blood-brain barrier in a multistep process that requires cells to pass through a perivascular …

The movement of lymphocytes from the microvasculature into the central nervous system
(CNS) parenchyma is an essential step in the pathogenesis of a variety of infectious and …

Experimental autoimmune encephalomyelitis (EAE) is a CD4+ Th1 T cell-mediated disease
of the CNS, used to study certain aspects of multiple sclerosis. CXCR3, the receptor for …

Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis,
a chronic inflammatory and demyelinating disease of the CNS. Albino Oxford (AO) rats are …

Inflammation within the central nervous system (CNS) is strictly controlled and if possible
prevented. Such a tight control is necessary due to high sensitivity of nervous tissue to …