The chemokines CXCL9 and CXCL10 bind to the common receptor CXCR3 and are
implicated in the pathogenesis of T‐cell‐mediated immunity in the central nervous system …

Cases of progressive multifocal leukoencephalopathy can occur in patients treated with the
B cell depleting anti-CD20 antibody, rituximab, highlighting the importance of B cell …

Chemokines are small proinflammatory cytokines that possess the ability to stimulate
migration of inflammatory cells towards the tissue site of inflammation. Previous reports …

Experimental autoimmune encephalomyelitis (EAE) is a CD4+ Th1-mediated demyelinating
disease of the CNS that serves as a model for multiple sclerosis. A critical event in the …

In multiple sclerosis (MS) and its animal model, experimental autoimmune
encephalomyelitis (EAE), autoaggressive T cells traffic into the CNS and induce disease …

Multiple sclerosis (MS) is an autoimmune disease of the CNS characterized by disruption of
the blood-brain barrier (BBB). This breach in CNS immune privilege allows undeterred …

Chemokines are a superfamily of chemotactic cytokines that play an important role in
leukocyte trafficking and have been implicated as functional mediators of immunopathology …

The chemokine, CXC motif ligand 13 (CXCL13), is constitutively expressed in lymphoid
organs and controls the recruitment and compartmentalization of lymphocytes and antigen …

Drugs that block leukocyte trafficking ameliorate multiple sclerosis (MS). Occurrences of
opportunistic infection, however, highlight the need for novel drugs that modulate more …

Understanding the mechanisms of immune cell migration to multiple sclerosis lesions offers
significant therapeutic potential. This study focused on the chemokines CXCL12 (SDF-1) …