Experimental autoimmune encephalomyelitis (EAE) is an inflammatory demyelinating
disease with similarities to multiple sclerosis (MS). It is induced in mice by the transfer of …

To study the biological role of the chemokine ligands CCL19 and CCL21, we generated
transgenic mice expressing either gene in oligodendrocytes of the CNS. While all transgenic …

There is increasing recognition of the important role that B cells play in the pathogenesis of
multiple sclerosis (MS). Recently it was reported that the B cell chemokine CXCL13 is …

Chemokines and their receptors play a critical role in orchestrating the immune response
during experimental autoimmune encephalomyelitis (EAE). Expression of CCR4 and its …

The CXC chemokine ligand (CXCL) 10 is induced locally in the CNS in diverse pathologic
states. The impact of CXCL10 production in the CNS was examined in transgenic mice with …

Current strategies for the treatment of demyelinating diseases such as multiple sclerosis
(MS) are based on anti‐inflammatory or immunomodulatory drugs. Those drugs have the …

Multiple sclerosis is a neurodegenerative disease characterized by episodes of autoimmune
attack of oligodendrocytes leading to demyelination and progressive functional deficits …

In neuro-inflammatory diseases, activated T cells are thought to drive the inflammatory
process. In this study, we investigated the potential role of three T cell attracting chemokines …

Experimental autoimmune encephalomyelitis is a T cell-mediated demyelinating disease of
the CNS that serves as a model for the human disease multiple sclerosis. Increased …

Increasing evidence points to an important role for neutrophils in participating in the
pathogenesis of the human demyelinating disease MS and the animal model EAE …