Abstract The Italian Longitudinal Study on Aging (ILSA) is a population-based, longitudinal
study of the health status of Italians aged 65–84 years. The main objectives of ILSA are the …

OBJECTIVES: To investigate whether higher circulating levels of C‐reactive protein (CRP),
interleukin‐6 (IL‐6), and α1‐antichymotrypsin (ACT) are associated with worse cognitive …

Ageing is accompanied by 2–4-fold increases in plasma/serum levels of inflammatory
mediators such as cytokines and acute phase proteins. A wide range of factors seems to …

OBJECTIVES: Several peripheral blood markers of inflammation have demonstrated
prognostic ability, but the value of combining multiple markers as a measure of inflammatory …

Background. Elevated plasma levels of interleukin (IL)-6, C-reactive protein (CRP), and D-
dimer belong to the biological alterations of the “frailty syndrome,” defining increased …

OBJECTIVES: To determine specific physiological correlates of the geriatric syndrome of
frailty that warrant further investigation. DESIGN: Population‐based case‐control study …

In the present investigation we have analyzed the association between functional
dependence and inflammatory biomarkers using the Barthel Index (BI) and the Katz Index …

Sarcopenia is an aged-related syndrome that is progressive and can be accelerated by
other concomitant disease states. Sarcopenia, characterized by loss of skeletal muscle …

Background Low grip strength is recognized as one of the characteristics of frailty, as are
systemic inflammation and the sensation of fatigue. Contrary to maximal grip strength, the …

Frailty is a geriatric syndrome defined as a status of extreme vulnerability to stressors,
leading to a higher risk of negative health-related outcomes.“Inflammaging”, an age-related …