Sialic acid analogues containing a unique chemical functionality or chemical reporter have
been metabolically incorporated into sialylated glycans. This process, termed metabolic …

Cell‐surface sialic acids are essential in mediating a variety of physiological and
pathological processes. Sialic acid chemistry and biology remain challenging to investigate …

Exo-enzymatic glycan labeling strategies have emerged as versatile tools for efficient and
selective installation of terminal glyco-motifs onto live cell surfaces. Through employing …

Sialic acids have diverse biological roles, ranging from promoting up to preventing protein
and cellular recognition in health and disease. The various functions of these …

Metabolic glycoengineering (MGE) is an established method to incorporate chemical
reporter groups into cellular glycans for subsequent bioorthogonal labeling. The method has …

In an era in which much of life-science research seems to sprint ahead by exploiting
postgenomic, systems-wide approaches, the glycobiologist's progress is often stymied by …

Sialic acid isomers attached in either α2, 3 or α2, 6 linkage to glycan termini confer distinct
chemical, biological, and pathological properties, but they cannot be distinguished by mass …

This report provides a perspective on metabolic glycoengineering methodology developed
over the past two decades that allows natural sialic acids to be replaced with chemical …

The analysis of sialylated glycans is critical for understanding the role of sialic acid in normal
biological processes as well as in disease. However, the labile nature of sialic acid typically …

Sialic acids cap the glycans of cell surface glycoproteins and glycolipids. They are involved
in a multitude of biological processes, and aberrant sialic acid expression is associated with …