Sequence-specific Ni (II)-dependent peptide bond hydrolysis for protein engineering: reaction conditions and molecular mechanism
E Kopera, A Krezel, AM Protas, A Belczyk… - Inorganic …, 2010 - ACS Publications
Recently we screened a combinatorial library of R1-(Ser/Thr)-Xaa-His-Zaa-R2 peptides
(Xaa= 17 common α-amino acids, except Asp, Glu, and Cys; Zaa= 19 common α-amino …
(Xaa= 17 common α-amino acids, except Asp, Glu, and Cys; Zaa= 19 common α-amino …
Sequence-specific Ni (II)-dependent peptide bond hydrolysis for protein engineering: Active sequence optimization
AM Protas, HHN Ariani, A Bonna… - Journal of inorganic …, 2013 - Elsevier
In previous studies we showed that Ni (II) ions can hydrolytically cleave a peptide bond
preceding Ser/Thr in peptides of a general sequence RN–(Ser/Thr)–Xaa–His–Zaa–RC …
preceding Ser/Thr in peptides of a general sequence RN–(Ser/Thr)–Xaa–His–Zaa–RC …
Sequence-specific Ni (II)-dependent peptide bond hydrolysis for protein engineering. Combinatorial library determination of optimal sequences
A Krezel, E Kopera, AM Protas… - Journal of the …, 2010 - ACS Publications
Previously we demonstrated for several examples that peptides having a general internal
sequence RN-Yaa-Ser/Thr-Xaa-His-Zaa-RC (Yaa= Glu or Ala, Xaa= Ala or His, Zaa= Lys …
sequence RN-Yaa-Ser/Thr-Xaa-His-Zaa-RC (Yaa= Glu or Ala, Xaa= Ala or His, Zaa= Lys …
Effect of d-Amino Acid Substitutions on Ni(II)-Assisted Peptide Bond Hydrolysis
HH Ariani, A Polkowska-Nowakowska… - Inorganic Chemistry, 2013 - ACS Publications
Previously we demonstrated the sequence-specific hydrolysis of the R1-(Ser/Thr)-peptide
bond in Ni (II) complexes of peptides with a general R1-(Ser/Thr)-Xaa-His-Zaa-R2 sequence …
bond in Ni (II) complexes of peptides with a general R1-(Ser/Thr)-Xaa-His-Zaa-R2 sequence …
Selective peptide bond hydrolysis of cysteine peptides in the presence of Ni (II) ions
Recently, we described a sequence-specific R1-(Ser/Thr) peptide bond hydrolysis reaction
in peptides of a general sequence R1–(Ser/Thr)–Xaa–His–Zaa–R, which occurs in the …
in peptides of a general sequence R1–(Ser/Thr)–Xaa–His–Zaa–R, which occurs in the …
Metal assisted peptide bond hydrolysis: Chemistry, biotechnology and toxicological implications
Metal-assisted hydrolysis of peptide bond is a promising alternative for enzymatic cleavage
of proteins with prospective applications in biochemistry and bioengineering. Many metal …
of proteins with prospective applications in biochemistry and bioengineering. Many metal …
[PDF][PDF] Sequence-specific Ni (II)-dependent peptide bond hydrolysis in a peptide containing threonine and histidine residues.
A Krezel, M Mylonas, E Kopera… - Acta Biochimica …, 2006 - frontierspartnerships.org
Previously we demonstrated that Ni (II) complexes of Ac-Thr-Glu-Ser-His-His-Lys-NH2
hexapeptide, representing residues 120–125 of human histone H2A, and some of its …
hexapeptide, representing residues 120–125 of human histone H2A, and some of its …
His-Oriented Peptide Hydrolysis Promoted by cis-[Pt(en)(H2O)2]2+: a New Specific Peptide Cleavage Site
The new specific hydrolysis of histidine-containing peptides promoted by cis-[Pt (en)(H2O) 2]
2+ was investigated by electrospray ionization mass spectrometry (ESI-MS) and nuclear …
2+ was investigated by electrospray ionization mass spectrometry (ESI-MS) and nuclear …
Axial hydrophobic fence in highly-stable Ni (II) complex of des-angiotensinogen N-terminal peptide
W Bal, GN Chmurny, BD Hilton… - Journal of the …, 1996 - ACS Publications
Angiotensinogen is a 66 kDa globular protein circulating in human blood with a
concentration of ca. 1 μg mL-1 (15 nM). 1 The kidney protease renin cleaves the N-terminal …
concentration of ca. 1 μg mL-1 (15 nM). 1 The kidney protease renin cleaves the N-terminal …
Theoretical Insights into the Mechanism of Selective Peptide Bond Hydrolysis Catalyzed by [Pd(H2O)4]2+
A Kumar, X Zhu, K Walsh, R Prabhakar - Inorganic chemistry, 2010 - ACS Publications
In this study, mechanisms for the hydrolysis of the Gly-Pro bond in Gly-Pro-Met and Gly-Pro-
His, the Gly-Sar bond in Gly-Sar-Met, and the Gly-Gly bond in the Gly-Gly-Met peptide …
His, the Gly-Sar bond in Gly-Sar-Met, and the Gly-Gly bond in the Gly-Gly-Met peptide …