Cytokines secreted at sites of inflammation impact the onset, progression, and resolution of
inflammation. In this article, we investigated potential proresolving mechanisms of IFN-γ in …

Summary Intact interleukin-10 receptor (IL-10R) signaling on effector and T regulatory (Treg)
cells are each independently required to maintain immune tolerance. Here we show that IL …

IL-10 is an immunomodulatory cytokine that plays an obligate role in preventing
spontaneous enterocolitis in mice. However, little is known about IL-10 function in the …

Background & Aims: Interleukin (IL)-10 is a cytokine with anti-inflammatory properties. The
aim of this study was to explore the effect of a site-specific delivery of IL-10 on intestinal …

Interleukin 10 (IL-10) is a pleiotropic, anti-inflammatory cytokine that has a major protective
role in the intestine. Although its production by cells of the innate and adaptive immune …

The healthy gut is achieved and maintained through a balanced relationship between the
mucosal immune system, microbial communities resident in the lumen, and the intestinal …

Inflammatory bowel disease (IBD) is characterized by chronic, uncontrolled inflammation in
the intestinal mucosa. Although the etiology is poorly understood, it is widely accepted that …

Background/Aims Active inflammatory bowel disease (IBD) is associated with increased
proinflammatory cytokines. Deficiency of interleukin (IL) 10, a contrainflammatory cytokine …

The appearance of chronic intestinal inflammation in IL-10 knockout mice suggests IL-10
may inhibit adverse responses to luminal antigen. Moreover, this inflammation is associated …

A deficiency in understanding the steps responsible for colitis is the lack of comprehension
for the role chemokines play in mucosal inflammation. IFN-γ-inducible protein-10 (IP-10) and …