Thoracic aortic aneurysm is a potentially life-threatening condition in that it places patients at
risk for aortic dissection or rupture. However, our modern understanding of the pathogenesis …

Aortic aneurysm, including both abdominal aortic aneurysm and thoracic aortic aneurysm, is
the cause of death of 1% to 2% of the Western population. This review focuses only on …

Thoracic aortic aneurysms leading to type A dissections (TAAD) can be inherited in isolation
or in association with genetic syndromes, such as Marfan syndrome and Loeys-Dietz …

Recent advances in DNA sequencing technology have identified several causative genes
for hereditary thoracic aortic aneurysms and dissections (TAADs), including Marfan …

Ascending thoracic aortic aneurysms leading to type A dissections (TAAD) can occur in
association with a genetic syndrome, such as Marfan syndrome (MFS), or as an autosomal …

Background: Thoracic aortic aneurysms progressively enlarge and predispose to acute
aortic dissections. Up to 25% of individuals with thoracic aortic disease harbor an underlying …

Genetic studies over the past several decades have helped to better elucidate the genomics
and inheritance of thoracic aortic diseases. Seminal work from various researchers have …

Aneurysms are characterized by structural deterioration of the vascular wall leading to
progressive dilatation and, potentially, rupture of the aorta. While aortic aneurysms often …

Genetic predisposition and risk factors such as hypertension and smoking can instigate the
development of thoracic aortic aneurysm (TAA), which can lead to highly lethal aortic wall …

Background: Aneurysms affecting the aorta are a common condition associated with high
mortality as a result of aortic dissection or rupture. Investigations of the pathogenic …