Leptin and cancer: from cancer stem cells to metastasis

J Park, PE Scherer - Endocrine-related cancer, 2011 - erc.bioscientifica.com
There is growing evidence that obesity is a risk factor of cancer incidence and mortality.
Hence, the identification of the mechanistic links between obesity and cancer progression is …

Leptin-induced signaling pathways in cancer cell migration and invasion

A Ghasemi, J Saeidi, M Azimi-Nejad, SI Hashemy - Cellular Oncology, 2019 - Springer
Background Increasing evidence indicates that obesity is associated with tumor
development and progression. Leptin is an adipocyte-related hormone with a key role in …

Leptin and cancer: updated functional roles in carcinogenesis, therapeutic niches, and developments

TC Lin, M Hsiao - International Journal of Molecular Sciences, 2021 - mdpi.com
Leptin is an obesity-associated adipokine that is known to regulate energy metabolism and
reproduction and to control appetite via the leptin receptor. Recent work has identified …

Oncogenic role and therapeutic target of leptin signaling in breast cancer and cancer stem cells

S Guo, M Liu, G Wang, M Torroella-Kouri… - … et Biophysica Acta (BBA …, 2012 - Elsevier
Significant correlations between obesity and incidence of various cancers have been
reported. Obesity, considered a mild inflammatory process, is characterized by a high level …

Obesity and cancer: Focus on leptin

K Ayed, L Nabi, R Akrout, H Mrizak, A Gorrab… - Molecular biology …, 2023 - Springer
Over the past decades, obesity has grown to epidemic proportions worldwide. It has been
associated with an increased risk for different types of cancer. In addition, obesity has been …

Leptin regulation of cancer stem cells in breast and gynecologic cancer

KK Crean-Tate, O Reizes - Endocrinology, 2018 - academic.oup.com
It is well established that obesity increases the incidence and worsens the prognosis of
women's cancer. For breast cancer, women with obesity exhibit more than a twofold …

Leptin: A heavyweight player in obesity-related cancers

A Caruso, L Gelsomino, S Panza, FM Accattatis… - Biomolecules, 2023 - mdpi.com
Obesity, defined as the abnormal or excessive expansion of white adipose tissue, has
reached pandemic proportions and is recognized as an important health concern since it is …

Leptin mediates tumor–stromal interactions that promote the invasive growth of breast cancer cells

I Barone, S Catalano, L Gelsomino, S Marsico… - Cancer research, 2012 - AACR
Obesity confers risks to cancer development and progression but the mechanisms
underlying these risks remain unclear. In this study, we identify a role for the obesity cytokine …

The multifactorial role of leptin in driving the breast cancer microenvironment

S Ando, S Catalano - Nature reviews endocrinology, 2012 - nature.com
Adipose-tissue-derived signaling molecules, including the adipokines, are emerging as key
candidate molecules that link obesity with cancer. Peritumoral, stromal, adipose tissue and …

[HTML][HTML] Leptin receptor signaling supports cancer cell metabolism through suppression of mitochondrial respiration in vivo

J Park, CM Kusminski, SC Chua, PE Scherer - The American journal of …, 2010 - Elsevier
Obesity represents a risk factor for certain types of cancer. Leptin, a hormone predominantly
produced by adipocytes, is elevated in the obese state. In the context of breast cancer, leptin …