Carboxylesterases (CESs) play major roles in catalyzing the hydrolysis of a wide range of
ester-and amide-containing compounds. CESs dominate both the biotransformation of …

Background: Carboxylesterases (CES) play a critical role in catalyzing hydrolysis of esters,
amides, carbamates and thioesters, as well as bioconverting prodrugs and soft drugs. The …

Mammalian carboxylesterases (CES), the key members of the serine hydrolase superfamily,
hydrolyze a wide range of endogenous substances and xenobiotics bearing ester or amide …

ABSTRACT Introduction Carboxylesterase 1 (CES1) and carboxylesterase 2 (CES2) are
among the most abundant hydrolases in humans, catalyzing the metabolism of numerous …

Abstract Carboxylesterases (CESs, EC 3.1. 1.1) constitute a large class of enzymes that
hydrolyze chemicals containing such a functional group as a carboxylic acid ester, amide …

Mammalian carboxylesterases (CEs) are key enzymes from the serine hydrolase
superfamily. In the human body, two predominant carboxylesterases (CES1 and CES2) …

Carboxylesterases (CE) are ubiquitous enzymes responsible for the detoxification of
xenobiotics, including numerous clinically used drugs. Therefore, the selective inhibition of …

Carboxylesterases (CE) are ubiquitous enzymes responsible for the detoxification of
xenobiotics. Many therapeutically useful drugs are metabolized by these proteins which …

Our understanding of the detailed recognition and processing of clinically useful therapeutic
agents has grown rapidly in recent years, and we are now able to begin to apply this …

In vitro inhibition studies on drug-metabolizing enzyme activity are useful for understanding
drug-drug interactions and for drug development. However, the profile of the inhibitory …