A prodrug is a pharmacologically inactive derivative of an active parent drug, and is
bioconverted to the active drug in vivo. Through chemical modification of a drug to a …

Carboxylesterases (CE) are members of the esterase family of enzymes, and as their name
suggests, they are responsible for the hydrolysis of carboxylesters into the corresponding …

Two major forms of human carboxylesterase (CES), CES1A and CES2, dominate the
pharmacokinetics of most prodrugs such as imidapril and irinotecan (CPT-11). Excipients …

INTRODUCTION: The effects of buffer and substrate solvent conditions on in vitro activity of
carboxylesterases (CE) have not been previously described. Therefore, it is unknown if the …

Background: Herbal products have grown steadily across the globe and have increasingly
been incorporated into western medicine for healthcare aims, thereby causing potential …

Carboxylesterases (CE) are ubiquitous enzymes thought to be responsible for the
metabolism and detoxification of xenobiotics. Numerous clinically used drugs including …

Esterases catalyze the hydrolysis of therapeutic drugs containing esters or amides in their
structures. Human carboxylesterase (CES) and arylacetamide deacetylase (AADAC) are the …

Human carboxylesterase (CES) 1A and CES2, two major forms of human CES, dominate the
pharmacokinetics of most prodrugs such as imidapril and irinotecan (CPT-11) …

Carboxylesterases are a multigene family of mammalian enzymes widely distributed
throughout the body that catalyze the hydrolysis of esters, amides, thioesters, and …

The aims of this study were to develop a robust method for simultaneous quantification of
carboxylesterases (CESs) 1 and 2 and to quantify those absolute protein levels in human …