Lungs are pharmacologically active organs and the pulmonary drug metabolism is of
interest for inhaled drugs design. Carboxylesterases (CESs) are enzymes catalyzing the …

Carboxylesterases (CEs) are traditionally regarded as xenobiotic metabolizing enzymes that
hydrolyze esterified xenobiotics to alcohol and carboxylic acid products. However, there is a …

Carboxylesterases (CE) are ubiquitous enzymes that hydrolyze numerous ester-containing
xenobiotics, including complex molecules, such as the anticancer drugs irinotecan (CPT-11) …

Inhibition of intestinal carboxylesterases may allow modification of the pharmacokinetics/
pharmacodynamic profile of existing drugs by altering half-life or toxicity. Since previously …

Abstract Carboxylesterase 2 (CES 2), plays a pivotal role in endobiotic homeostasis and
xenobiotic metabolism. Protostanes, the major constituents of the genus Alisma, display a …

Several mouse carboxylesterase (CES) isozymes have been identified, but information
about their roles in drug metabolism is limited. In this study, we purified and characterized a …

Carboxylesterases (CES) metabolize esters. Two CES isoforms are expressed in human
liver (CES1 and CES2) and liver extracts are used in reaction phenotyping studies to discern …

Carboxylesterases belong to Phase I group of drug metabolizing enzymes. They hydrolyze a
variety of drug esters, amides, carbamates and similar structures. There are five …

The cynomolgus monkey is a nonhuman primate that is often used for pharmacokinetic and
toxicokinetic studies of new chemical entities. Species differences in drug metabolism are …

The primary functions of carboxylesterases rest in two modes of action–catalytic and
interacting proteins [1–3]. As enzymes, carboxylesterases catalyze both hydrolytic and …