Drug delivery for Alzheimer's disease using nanotechnology: Challenges and advancements

B Chauhan, S Patel, BG Prajapati, S Singh - Alzheimer's Disease and …, 2024 - Elsevier
Alzheimer's disease (AzD) is the most common type of dementia among older adults, with a
progressive disorder of brain that affect thinking ability, behavior, and memorizing capability …

[HTML][HTML] Brain-targeted polysorbate 80-emulsified donepezil drug-loaded nanoparticles for neuroprotection

X Tao, S Mao, Q Zhang, H Yu, Y Li, X He… - Nanoscale Research …, 2021 - Springer
Most Alzheimer's disease drugs do not work efficiently because of the blood–brain barrier.
Therefore, we designed a new nanopreparation (PS-DZP-CHP): cholesterol-modified …

[HTML][HTML] ApoE-targeting increases the transfer of solid lipid nanoparticles with donepezil cargo across a culture model of the blood–brain barrier

GR Topal, M Mészáros, G Porkoláb, A Szecskó… - Pharmaceutics, 2020 - mdpi.com
Pharmacological treatment of central nervous system (CNS) disorders is difficult, because
the blood–brain barrier (BBB) restricts the penetration of many drugs into the brain. To solve …

Advanced nanoparticular approaches to combat Alzheimer's disease

R Shah, S Bhattacharya - Pharmaceutical Nanotechnology, 2021 - ingentaconnect.com
Alzheimer's disease (AD) is a neurological disease that affects many of the world's rapidly
ageing population. In the etiology of Alzheimer's disease (AD), the involvement of amyloid β …

[HTML][HTML] Current and future nano-carrier-based approaches in the treatment of Alzheimer's disease

A Kumar, ST Sudevan, AS Nair, AK Singh, S Kumar… - Brain Sciences, 2023 - mdpi.com
It is a very alarming situation for the globe because 55 million humans are estimated to be
affected by Alzheimer's disease (AD) worldwide, and still it is increasing at the rapid speed …

Reassembly of native components with donepezil to execute dual-missions in Alzheimer's disease therapy

H Zhang, Y Zhao, M Yu, Z Zhao, P Liu, H Cheng… - Journal of controlled …, 2019 - Elsevier
Alzheimer's disease (AD) is a multifaceted and progressive neurodegenerative disease
characterized by accumulation of amyloid-beta (Aβ) and deficits of acetylcholine …

Dual-functional nanoparticles for precise drug delivery to Alzheimer's disease lesions: Targeting mechanisms, pharmacodynamics and safety

X Zheng, C Zhang, Q Guo, X Wan, X Shao, Q Liu… - International journal of …, 2017 - Elsevier
Alzheimer's disease (AD) is the most common form of dementia and is characterized by the
cerebral accumulation of extracellular amyloid plaques. In a previous study, this …

Advancements in nanotherapeutics for Alzheimer's disease: current perspectives

S Harilal, J Jose, DGT Parambi, R Kumar… - Journal of Pharmacy …, 2019 - academic.oup.com
Objectives Considerable progress has been made in the treatment of Alzheimer's disease
(AD), but all available strategies focus on alleviating symptoms rather than curing, which …

Therapeutic strategies and nano-drug delivery applications in management of ageing Alzheimer's disease

G Karthivashan, P Ganesan, SY Park, JS Kim… - Drug …, 2018 - Taylor & Francis
In recent years, the incidental rate of neurodegenerative disorders has increased
proportionately with the aging population. Alzheimer's disease (AD) is one of the most …

Neurotherapeutic applications of nanoparticles in Alzheimer's disease

JK Sahni, S Doggui, J Ali, S Baboota, L Dao… - Journal of Controlled …, 2011 - Elsevier
A rapid increase in incidence of neurodegenerative disorders has been observed with the
aging of the population. Alzheimer's disease (AD) is the most common neurodegenerative …