Highlights•Alzheimer's disease (AD) is drastically lacking of curative treatment.•The interest
of nanocarriers for the approved drugs in AD treatment has been shown.•Drug repurposing …

In this work, the graft copolymer, poly (vinyl alcohol)-grafted polyacrylamide (PVA-g-PAAm),
was synthesized and characterized by Fourier transform infrared spectroscopy, differential …

Traditional drug delivery approaches remained ineffective in offering better treatment to
various neurodegenerative disorders (NDs). In this context, diverse types of nanocarriers …

Dexibuprofen loaded pegylated poly (lactic-co-glycolic) nanospheres prepared by solvent
diffusion method were designed to increase Dexibuprofen brain delivery reducing systemic …

Drug delivery to the brain still remains highly challenging for the treatment of Alzheimer's
disease (AD). The development of new practical treatment modalities for the treatment of AD …

Dementia impairs memory, critical thinking, and decision-making. Alzheimer's disease is
caused by extracellular amyloid fibrils containing the peptide Amyloid beta (Aβ) …

Donepezil (DPZ) is widely used in the treatment of Alzheimer's disease in tablet form for oral
administration. The pharmacological efficacy of this drug can be enhanced by the use of …

Alzheimer's disease (AD) is a deadly, progressive, and irreversible brain condition that
impairs cognitive abilities. Globally, it affects 32.6 million individuals, and if no viable …

The purpose of this work is to prepare donepezil microparticles (DM) and evaluate its
advantage as a sustained release delivery system with subcutaneous injection once a …

Objective The first aim of this study was to develop a nanocarrier that could transport the
peroxisome proliferator-activated receptor agonist, pioglitazone (PGZ) across brain …