Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases

JA Smith, A Das, SK Ray, NL Banik - Brain research bulletin, 2012 - Elsevier
Microglia are activated in response to a number of different pathological states within the
CNS including injury, ischemia, and infection. Microglial activation results in their production …

Microglia-mediated neuroinflammation in neurodegenerative diseases

CS Subhramanyam, C Wang, Q Hu… - Seminars in cell & …, 2019 - Elsevier
Microglia, being the resident immune cells of the central nervous system, play an important
role in maintaining tissue homeostasis and contributes towards brain development under …

Role of microglia in neurological disorders and their potentials as a therapeutic target

L Du, Y Zhang, Y Chen, J Zhu, Y Yang… - Molecular neurobiology, 2017 - Springer
Microglia are resident macrophage-like immune cells in the central nervous system (CNS)
and play a vital role in both physiological and pathological conditions, including restoring …

Role of inflammation in neurodegenerative diseases

L Minghetti - Current opinion in neurology, 2005 - journals.lww.com
Although significant advances have been made in our knowledge of degenerative diseases,
there remains controversy regarding whether neuroinflammation and microglial activation …

Microglia and neurodegeneration: the role of systemic inflammation

C Cunningham - Glia, 2013 - Wiley Online Library
It is well accepted that CNS inflammation has a role in the progression of chronic
neurodegenerative disease, although the mechanisms through which this occurs are still …

[HTML][HTML] Microglia phenotypes in aging and neurodegenerative diseases

MY Wendimu, SB Hooks - Cells, 2022 - mdpi.com
Neuroinflammation is a hallmark of many neurodegenerative diseases (NDs) and plays a
fundamental role in mediating the onset and progression of disease. Microglia, which …

Recent progress in therapeutic strategies for microglia-mediated neuroinflammation in neuropathologies

N Gupta, S Shyamasundar, R Patnala… - Expert opinion on …, 2018 - Taylor & Francis
Introduction: Chronic activation of microglia is the hallmark of numerous neuropathologies
such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. The activated …

The role of microglia in the development of neurodegeneration

AR Saitgareeva, KV Bulygin, IF Gareev, OA Beylerli… - Neurological …, 2020 - Springer
Microglia-mediated central nervous system (CNS) inflammation is one of the key features of
various neurodegenerative diseases, including Parkinson's and Alzheimer's diseases. In the …

Microglia biology in health and disease

GA Garden, T Möller - Journal of Neuroimmune Pharmacology, 2006 - Springer
Microglia cells are resident central nervous system (CNS) leukocytes that regulate innate
immunity and participate in adaptive immune responses in CNS tissue. However, microglia …

[HTML][HTML] Microglia in neurological diseases: a road map to brain-disease dependent-inflammatory response

S Bachiller, I Jiménez-Ferrer, A Paulus… - Frontiers in cellular …, 2018 - frontiersin.org
Microglia represent a specialized population of macrophages-like cells in the central
nervous system (CNS) considered immune sentinels that are capable of orchestrating a …