Background Cerebrospinal fluid (CSF) has been considered as a preferential pathway of
circulation for immune cells during neuroimmune surveillance. In order to evaluate the …

Objective The management of complex patients with neuroimmunological diseases is
hindered by an inability to reliably measure intrathecal inflammation. Currently implemented …

Neuroinflammation is the response of the central nervous system (CNS) to disturbed
homeostasis and typifies all neurological diseases. The main reactive components of the …

The concept of central nervous system (CNS) inflammation has evolved over the last
decades. Neuroinflammation is the response of reactive CNS components to altered …

Neuroinflammation has been suggested as an attractive treatment target in stroke, since it
offers a broader therapeutic window in comparison to currently established thrombolytic …

Neurodegeneration, the slow and progressive dysfunction and loss of neurons and axons in
the central nervous system, is the primary pathological feature of acute and chronic …

Background: Multiple sclerosis (MS) biomarker identification is important for pathogenesis
research and diagnosis in routine clinical practice. Cerebrospinal fluid (CSF) and blood …

The central nervous system (CNS) is now known to actively communicate with the immune
system to control immune responses both centrally and peripherally. Within the CNS, while …

We performed unbiased, comprehensive immunophenotyping of cerebrospinal fluid (CSF)
and blood leukocytes in 221 subjects referred for the diagnostic work-up of …

There is an increasing recognition that inflammation plays a critical role in
neurodegenerative diseases of the CNS, including Alzheimer's disease, amyotrophic lateral …