The prostate is an exocrine gland of the male reproductive system dependent on androgens
(testosterone and dihydrotestosterone) for development and maintenance. First-line therapy …

Due to its dependence on androgens, metastatic prostate cancer is typically treated with
continuous androgen ablation. However, such therapy eventually fails due to the emergence …

Prostate cancer is one of the most prevalent cancers in men, with increasing incidence
worldwide. This public health concern has inspired considerable effort to study various …

We review and synthesize key findings and limitations of mathematical models for prostate
cancer, both from theoretical work and data-validated approaches, especially concerning …

Prostate cancer is commonly treated by a form of hormone therapy called androgen
suppression. This form of treatment, while successful at reducing the cancer cell population …

Predicting the timing of a castrate resistant prostate cancer is critical to lowering medical
costs and improving the quality of life of advanced prostate cancer patients. We formulate …

Androgen deprivation therapy is a common treatment for advanced or metastatic prostate
cancer. Like the normal prostate, most tumors depend on androgens for proliferation and …

Prostate cancer progression depends in part on the complex interactions between
testosterone, its active metabolite DHT, and androgen receptors. In a metastatic setting, the …

In this paper, we formulate a three cell population model of intermittent androgen
suppression therapy for cancer patients to study the treatment resistance development. We …

Prostate cancer is one of the most prevalent types of cancer among men. It is stimulated by
the androgens, or male sexual hormones, which circulate in the blood and diffuse into the …