Glucocorticoid therapy for asthma: clinical pharmacology

SJ Szefler - Journal of allergy and clinical immunology, 1991 - Elsevier
We are now well aware that inflammation plays an important role in the pathogenesis of
asthma. This awareness comes at a time when we question the etiology of increased …

Issues in the use of inhaled glucocorticoids. The Asthma Clinical Research Network.

AK Kamada, SJ Szefler, RJ Martin… - American journal of …, 1996 - atsjournals.org
Asthma is now regarded as an inflammatory disease, and inhaled glucocorticoids (iGCs) are
recommended earlier in the course of treatment of patients with this disorder. Although iGCs …

Adverse effects of inhaled corticosteroids

NA Hanania, KR Chapman, S Kesten - The American journal of medicine, 1995 - Elsevier
Inhaled corticosteroids are considered by many to be the anti-inflammatory therapy of choice
in adult asthma, given their remarkable efficacy and apparent safety. They are presently …

Inhaled corticosteroids: impact on asthma morbidity and mortality

S Suissa, P Ernst - Journal of Allergy and Clinical Immunology, 2001 - Elsevier
Inhaled corticosteroids are now recommended as first-line therapy for asthma. Although
these drugs clearly improve the symptoms of the disease and the associated physiologic …

Clinical pharmacology of corticosteroids

DM Williams - Respiratory care, 2018 - rc.rcjournal.com
Corticosteroids have numerous applications in treating inflammation and diseases of
immune function based on their significant anti-inflammatory and immunosuppressive …

Establishing a therapeutic index for the inhaled corticosteroids: part I: pharmacokinetic/pharmacodynamic comparison of the inhaled corticosteroids

HW Kelly - Journal of allergy and clinical immunology, 1998 - Elsevier
The inhaled corticosteroids contain physicochemical differences that alter both
glucocorticoid receptor-binding characteristics and the pharmacokinetic variables of these …

Inhaled corticosteroid doses in asthma: an evidence‐based approach

H Powell, PG Gibson - Medical journal of Australia, 2003 - Wiley Online Library
Objective: To define the evidence for doses of inhaled corticosteroids in asthma and
describe this in clinically meaningful, evidence‐based terms. Data source: Cochrane …

Asthma and corticosteroid responses in childhood and adult asthma

AA Ramadan, JM Gaffin, E Israel… - Clinics in chest …, 2019 - chestmed.theclinics.com
Asthma is a chronic respiratory disease affecting approximately 300 million people
worldwide. 1 In the United States, an estimated 43.3 million people, including 9.3 million …

Inhaled corticosteroids and asthma control in children: assessing impairment and risk

G Rachelefsky - Pediatrics, 2009 - publications.aap.org
OBJECTIVE. To review the use of inhaled corticosteroids on asthma control in children by
using the new therapeutic paradigm outlined in the Expert Panel Report 3: Guidelines for the …

Clinical safety of inhaled corticosteroids for asthma in children: an update of long-term trials

S Pedersen - Drug safety, 2006 - Springer
Inhaled corticosteroids are established as the mainstay of maintenance therapy for chronic
asthma. However, there remains some debate regarding the safety of long-term use of these …