A small number of physiologically important ATP-binding cassette (ABC) transporters are
found in mitochondria. Most are half transporters of the B group forming homodimers and …

The human lysosomal polypeptide ABC transporter TAPL (ABC subfamily B member 9,
ABCB9) transports 6–59-amino-acid-long polypeptides from the cytosol into lysosomes. The …

BtuB, the cobalamin transporter from Escherichia coli, has been overexpressed, purified and
crystallized. The purified protein was solubilized in n-octyl tetraoxyethylene (C8E4) and was …

ABCB4 is an ATP-binding cassette transporter that extrudes phosphatidylcholine into the
bile canaliculi of the liver. Its dysfunction or inhibition by drugs can cause severe, chronic …

ABC transporters fulfill diverse physiological functions in different cellular localizations
ranging from the plasma membrane to intracellular membranous compartments. Several …

We report the isolation and structural characterization of the full-length gene and cDNA for a
novel mouse ATP-binding cassette (ABC) transporter, Abca13. The mRNA, isolated from …

Vitamin B12 (cobalamin) is the most complex B-type vitamin and is synthetized exclusively
in a limited number of prokaryotes. Its biologically active variants contain rare organometallic …

Cobalamin (Cbl, vitamin B12) serves for two essential cofactors in mammals. The pathway
for its intestinal absorption, plasma transport, and cellular uptake uses cell surface receptors …

In all kingdoms of life, ATP binding cassette (ABC) transporters are essential to many
cellular functions. In this large superfamily of proteins, two catalytic sites hydrolyze ATP to …

BtuCD is a type II ABC importer that catalyzes the translocation of vitamin B12 from the
periplasm into the cytoplasm of Escherichia coli. Crystal structures of BtuCD and the related …