[HTML][HTML] W546 stacking disruption traps the human porphyrin transporter ABCB6 in an outward-facing transient state
SS Lee, JG Park, E Jang, SH Choi, S Kim… - Communications …, 2023 - nature.com
Human ATP-binding cassette transporter subfamily B6 (ABCB6) is a mitochondrial ATP-
driven pump that translocates porphyrins from the cytoplasm into mitochondria for heme …
driven pump that translocates porphyrins from the cytoplasm into mitochondria for heme …
[HTML][HTML] Conformational coupling of the nucleotide-binding and the transmembrane domains in ABC transporters
PC Wen, E Tajkhorshid - Biophysical journal, 2011 - cell.com
Basic architecture of ABC transporters includes two transmembrane domains (TMDs) and
two nucleotide-binding domains (NBDs). Although the transport process takes place in the …
two nucleotide-binding domains (NBDs). Although the transport process takes place in the …
[HTML][HTML] Structural insights into porphyrin recognition by the human ATP-binding cassette transporter ABCB6
S Kim, SS Lee, JG Park, JW Kim, S Ju, SH Choi… - Molecules and cells, 2022 - Elsevier
Human ABCB6 is an ATP-binding cassette transporter that regulates heme biosynthesis by
translocating various porphyrins from the cytoplasm into the mitochondria. Here we report …
translocating various porphyrins from the cytoplasm into the mitochondria. Here we report …
Kinetics of p-mercuribenzoate binding to sulfhydryl groups on the isolated cytoplasmic fragment of band 3 protein: effect of hemoglobin binding on the conformation
JM Salhany, R Cassoly - Journal of Biological Chemistry, 1989 - ASBMB
Hemoglobin binds to the cytoplasmic domain of band 3 protein (CDB3) at physiologic pH
and ionic strength in an oxygen-linked fashion, with deoxyhemoglobin having the higher …
and ionic strength in an oxygen-linked fashion, with deoxyhemoglobin having the higher …
Structure of an ABC transporter in complex with its binding protein
K Hollenstein, DC Frei, KP Locher - Nature, 2007 - nature.com
ATP-binding cassette (ABC) transporter proteins carry diverse substrates across cell
membranes. Whereas clinically relevant ABC exporters are implicated in various diseases …
membranes. Whereas clinically relevant ABC exporters are implicated in various diseases …
[HTML][HTML] Quantification of volume and lipid filling of intracellular vesicles carrying the ABCA3 transporter
S Höppner, S Kinting, AA Torrano… - … et Biophysica Acta (BBA …, 2017 - Elsevier
The ABCA3 lipid transporter is located in the limiting membrane of lamellar bodies (LBs) in
type-II-pneumocytes. Mutations within the ABCA3 gene may functionally impair the …
type-II-pneumocytes. Mutations within the ABCA3 gene may functionally impair the …
ABCG2 membrane transporter in mature human erythrocytes is exclusively homodimer
ML Leimanis, E Georges - Biochemical and biophysical research …, 2007 - Elsevier
The human ABCG2 protein, a member of ABC transporter family, was shown to transport anti-
cancer drugs and normal cell metabolites. Earlier studies have demonstrated the expression …
cancer drugs and normal cell metabolites. Earlier studies have demonstrated the expression …
Molecular cDNA cloning and tissue distribution of mRNA encoding a novel ATP-binding cassette (ABC) half-transporter
KI Hirsch-Ernst, S Gaini-Rahimi, BP Ernst… - Biochemical and …, 1998 - Elsevier
The majority of proteins belonging to theATP-bindingcassette (ABC) superfamily catalyzes
translocation of substrates across biological membranes. Employing a reverse transcription …
translocation of substrates across biological membranes. Employing a reverse transcription …
[HTML][HTML] Optimized purification of a heterodimeric ABC transporter in a highly stable form amenable to 2-D crystallization
C Galián, F Manon, M Dezi, C Torres, C Ebel, D Lévy… - PloS one, 2011 - journals.plos.org
Optimized protocols for achieving high-yield expression, purification and reconstitution of
membrane proteins are required to study their structure and function. We previously reported …
membrane proteins are required to study their structure and function. We previously reported …
[HTML][HTML] Extracellular ATP regulates CD73 and ABCC6 expression in HepG2 cells
F Martinelli, F Cuviello, MC Pace… - Frontiers in molecular …, 2018 - frontiersin.org
The ATP-binding cassette sub-family C member 6 transporter (ABCC6) is an ATP dependent
transporter mainly found in the basolateral plasma membrane of hepatic and kidney cells …
transporter mainly found in the basolateral plasma membrane of hepatic and kidney cells …