Vitamin B12 transport from food to the body's cells—a sophisticated, multistep pathway

MJ Nielsen, MR Rasmussen, CBF Andersen… - Nature reviews …, 2012 - nature.com
Abstract Vitamin B12 (B12; also known as cobalamin) is a cofactor in many metabolic
processes; deficiency of this vitamin is associated with megaloblastic anaemia and various …

Predicting ligand interactions with ABC transporters in ADME

MA Demel, O Krämer, P Ettmayer… - Chemistry & …, 2009 - Wiley Online Library
ABC‐type drug efflux pumps, eg, ABCB1 (= P‐glycoprotein,= MDR1), ABCC1 (= MRP1), and
ABCG2 (= MXR,= BCRP), confer a multi‐drug resistance (MDR) phenotype to cancer cells …

ABCA1 is an extracellular phospholipid translocase

JP Segrest, C Tang, HD Song, MK Jones… - Nature …, 2022 - nature.com
Production of high density lipoprotein (HDL) requires ATP-binding cassette transporter A1
(ABCA1) to drive phospholipid (PL) from the plasma membrane into extracellular …

Insights into lysosomal cobalamin trafficking: lessons learned from cblF disease

S Gailus, W Höhne, B Gasnier, P Nürnberg… - Journal of molecular …, 2010 - Springer
Vitamin B 12 (cobalamin) is essential in animals and humans for metabolism of
methylmalonic acid, for the remethylation of homocysteine to methionine and, consequently …

[图书][B] ABC transporters-40 years on

AM George - 2016 - Springer
This new book on ABC transporters represents a milestone in research into this important
family of membrane proteins that are engaged in either the import or export of substrates …

[HTML][HTML] The ABCA subclass of mammalian transporters

C Broccardo, MF Luciani, G Chimini - Biochimica et Biophysica Acta (BBA) …, 1999 - Elsevier
We describe here a subclass of mammalian ABC transporters, the ABCA subfamily. This is a
unique group that, in contrast to any other human ABC transporters, lacks a structural …

[HTML][HTML] Structural features of the ATP-binding cassette (ABC) transporter ABCA3

A Paolini, A Baldassarre, I Del Gaudio… - International Journal of …, 2015 - mdpi.com
In this review we reported and discussed the structural features of the ATP-Binding Cassette
(ABC) transporter ABCA3 and how the use of bioinformatics tools could help researchers to …

Impact of cblB mutations on the function of ATP: cob (I) alamin adenosyltransferase in disorders of vitamin B12 metabolism

J Zhang, CM Dobson, X Wu, J Lerner-Ellis… - Molecular genetics and …, 2006 - Elsevier
ATP: cob (I) alamin adenosyltransferase (MMAB protein; methylmalonic aciduria type B) is
an enzyme of vitamin B12 metabolism that converts reduced cob (I) alamin to the …

ABCA6, a novel a subclass ABC transporter

WE Kaminski, JJ Wenzel, A Piehler… - Biochemical and …, 2001 - Elsevier
Here we report the cDNA cloning of a novel member of the ABC A transporter subfamily from
human macrophages. The identified coding sequence is of 5.0 kb size and contains an open …

ABCB6, an ABC transporter impacting drug response and disease

RC Boswell-Casteel, Y Fukuda, JD Schuetz - The AAPS journal, 2018 - Springer
Recent findings have discovered how insufficiency of ATP-binding cassette (ABC)
transporter, ABCB6, can negatively impact human health. These advances were made …