Upregulation of heme oxygenase-1 by Epigallocatechin-3-gallate via the phosphatidylinositol 3-kinase/Akt and ERK pathways

CC Wu, MC Hsu, CW Hsieh, JB Lin, PH Lai, BS Wung - Life sciences, 2006 - Elsevier
Heme oxygenase-1 (HO-1) is a cytoprotective enzyme activated by various phytochemicals
and we examined the ability of Epigallocatechin-3-gallate (EGCG), the major constituent of …

[HTML][HTML] Epigallocatechin activates haem oxygenase-1 expression via protein kinase Cδ and Nrf2

RM Ogborne, SA Rushworth, MA O'Connell - Biochemical and Biophysical …, 2008 - Elsevier
The Nrf2/anti-oxidant response element (ARE) pathway plays an important role in regulating
cellular anti-oxidants, including haem oxygenase-1 (HO-1). Various kinases have been …

Epigallocatechin gallate induces expression of heme oxygenase-1 in endothelial cells via p38 MAPK and Nrf-2 that suppresses proinflammatory actions of TNF-α

P Pullikotil, H Chen, R Muniyappa… - The Journal of …, 2012 - Elsevier
Epigallocatechin gallate (EGCG), the major polyphenol in green tea, acutely stimulates
production of nitric oxide (NO) from vascular endothelium to reduce hypertension and …

Piceatannol upregulates endothelial heme oxygenase-1 expression via novel protein kinase C and tyrosine kinase pathways

BS Wung, MC Hsu, CC Wu, CW Hsieh - Pharmacological Research, 2006 - Elsevier
Piceatannol is an anti-inflammatory and anti-proliferative plant-derived stilbene. Heme
oxygenase-1 (HO-1) is a cytoprotective enzyme to activate by various phytochemicals. In this …

Differential activation of heme oxygenase-1 by chalcones and rosolic acid in endothelial cells

R Foresti, M Hoque, D Monti, CJ Green… - Journal of Pharmacology …, 2005 - ASPET
The induction of heme oxygenase-1 (HO-1) is widely recognized as an effective cellular
strategy to counteract a variety of stressful events. We have shown that curcumin and caffeic …

Constitutive overexpression of Nrf2-dependent heme oxygenase-1 in A549 cells contributes to resistance to apoptosis induced by epigallocatechin 3-gallate

MH Kweon, VM Adhami, JS Lee, H Mukhtar - Journal of Biological …, 2006 - ASBMB
Epigallocatechin 3-gallate (EGC19194), the major polyphenol found in green tea, exerts
antiproliferative and proapoptotic effects in many cancer cells. However, we found that …

Induction of heme oxygenase-1 by Ginkgo biloba extract but not its terpenoids partially mediated its protective effect against lysophosphatidylcholine-induced damage

JX Chen, H Zeng, X Chen, CY Su, CC Lai - Pharmacological research, 2001 - Elsevier
In this study, we examined whether Ginkgo Biloba Extract and its terpenoid constituents
protect against oxidative stress through actions on heme oxygenase (HO) gene expression …

Involvement of Nrf2, p38, B-Raf, and nuclear factor-κB, but not phosphatidylinositol 3-kinase, in induction of hemeoxygenase-1 by dietary polyphenols

CK Andreadi, LM Howells, PA Atherfold… - Molecular …, 2006 - ASPET
The highly inducible enzyme, hemeoxygenase-1 (HO-1), metabolizes heme, thereby
protecting a variety of cells against oxidative stress and apoptosis. Up-regulation by cancer …

Upregulation of heme oxygenase-1 by brazilin via the phosphatidylinositol 3-kinase/Akt and ERK pathways and its protective effect against oxidative injury

BM Choi, BR Kim - European journal of pharmacology, 2008 - Elsevier
Heme oxygenase (HO)-1 is a cytoprotective enzyme that is activated by various
phytochemicals. We examined the ability of brazilin to upregulate HO-1 expression in …

Regulation of heme oxygenase-1 expression and MAPK pathways in response to kaempferol and rhamnocitrin in PC12 cells

JT Hong, JH Yen, L Wang, YH Lo, ZT Chen… - Toxicology and applied …, 2009 - Elsevier
Oxidative stress has been considered as a major cause of cellular injuries in a variety of
clinical abnormalities, especially neural diseases. Our aim of research is to investigate the …