The initial termination of cocaine consumption in human addicts is associated with
heightened anxiety states and low levels of craving. Craving, however, tends to increase …

Rationale: While several environmental situations may produce cocaine craving, there is
little research on whether patterns of drug cue reactivity are similar across different …

The development of addiction and vulnerability to relapse following withdrawal is proposed
to be the result of neuroadaptive processes within the central nervous system that oppose …

Two laboratory studies were conducted to examine the effects of acute psychological stress
on craving and stress reactivity in cocaine abusers. In the first preliminary study, we …

Rationale Successful treatment of cocaine addiction is severely impeded by the propensity
of users to relapse. Withdrawal severity may serve as a key predictor of susceptibility to …

Anxiety is a key symptom of the cocaine withdrawal syndrome in human addicts, and it is
considered to be one of the major factors in precipitating relapse to chronic cocaine abuse …

Stress and drug-associated cues can trigger drug desire and relapse in abstinent cocaine
users. Although the role of these two factors in relapse is well documented, it remains …

Chronic exposure to cocaine is associated with neuroadaptions in stress and reward circuits
that may increase susceptibility to relapse. We examined whether there are alterations in …

Rationale Environmental stimuli associated with cocaine are known to elicit drug craving
and increase the likelihood of relapse. However, the psychobiological changes that occur …

Cocaine addiction is an enduring, relapsing, behavioural disorder in which stressors
reinstate cocaine‐seeking even after prolonged abstinence. Evidence suggests that the …