The events of cell reproduction are governed by oscillations in the activities of cyclin-
dependent kinases (Cdks). Cdks control the cell cycle by catalysing the transfer of …

Inhibitors, activators, and substrates of cyclin-dependent kinases (cdks) utilize a cyclin-
binding sequence, known as a Cy or RXL motif, to bind directly to the cyclin subunit. Alanine …

Abstract Cyclin‐dependent kinase 5 (cdk5), in contrast to other members of the cyclin‐
dependent kinase family, is not activated by cyclins but instead is activated by complexing …

The cyclin-dependent kinases 4 and 6 (Cdk4/6) that control the G1 phase of the cell cycle
and their inhibitor, the p16INK4a tumour suppressor, have a central role in cell proliferation …

DNA replication and mitosis are dependent on the activity of cyclin-dependent protein
kinase (CDK) enzymes, which are heterodimers of a catalytic subunit with a cyclin subunit …

THE eukaryotic cell cycle is regulated by the sequential activation of cyclin-dependent
kinases (CDKs) 1. CDK activation is dependent on cyclin binding2–4 and phosphorylation of …

Deregulation of cell proliferation is a hallmark of neoplastic transformation. Alteration in
growth control pathways must translate into changes in the cell-cycle regulatory machinery …

Cyclin-dependent kinases (CDKs) limit the activation of DNA replication origins to once per
cell cycle by preventing the assembly of pre-replicative complexes (pre-RCs) during S, G2 …

Cyclin-dependent kinases regulate the cell cycle and transcription in higher eukaryotes. We
have determined the crystal structure of the transcription kinase Cdk13 and its Cyclin K …

A number of low molecular weight proteins have recently been identified that specifically
inhibit the function of cyclin-dependent protein kinases in mammalian cells. These fall into …