Background/Aims: Caffeic acid (CA) is known to possess multiple biological activities
including anti-cancer activities. However, the molecular mechanisms underlying these …

Caffeic acid (CA), a natural phenolic compound, is abundant in medicinal plants. CA
possesses multiple biological effects such as anti-bacterial and anti-cancer growth. CA was …

Caffeine is one of the most widely consumed substances found in beverages, and has
demonstrated anticancer effects in several types of cancer. The present study aimed to …

Background Cisplatin is an important DNA-damaging anticancer drug that has been used to
treat many cancer types. However, the effectiveness of cisplatin treatment diminishes quickly …

Cutaneous melanoma (CM) is an extremely aggressive cancer presenting low survival and
high mortality. The vast majority of patients affected by this disease does not respond or …

Methylxantine derivative, caffeine, is known to prevent the p53‐dependent apoptosis
pathway via inhibition of ATM (ataxia telangiectasia mutated) kinase, which activates p53 by …

Melanoma is highly metastatic and resistant to chemotherapeutic drugs. Our previous
studies have demonstrated that caffeic acid phenethyl ester (CAPE) suppresses the growth …

Evidence is growing for the beneficial role of selective estrogen receptor modulators (SERM)
in prostate diseases. Caffeic acid phenethyl ester (CAPE) is a promising component of …

Background While multiagent chemotherapy has dramatically improved the prognosis of
sarcoma, the novel chemotherapeutics have hardly developed over the past 30 years …

Background: Caffeic Acid Phenethyl Ester (CAPE), an active extract of propolis, has recently
been reported to have broad applications in various cancers. However, the effects of CAPE …