Excessive tissue lactic acidosis has earlier been shown to aggravate structural damage of
both neurons and glial cells in the rat cerebral cortex. To study the reactions of cortical …

The influence of severe tissue lactic acidosis during incomplete brain ischemia (30 min) on
cortex morphology was studied in fasted rats. Production of lactate in the ischemic tissue …

Transient severe incomplete ischemia was induced in rats by a combination of bilateral
carotid artery clamping and hypovolemic hypotension. Production of lactic acid in the …

Severe incomplete cerebral ischemia of 30 min duration with CBF below 5% of normal was
induced in rats by clamping both carotids and lowering BP. One group of rats were fasting (f …

This study explores the influence of severe lactic acidosis in the ischemic rat brain on
postischemic recovery of the tissue energy state and neurophysiological parameters. Severe …

Brain cells are better protected against systemic acidosis (and alkalosis) than most other
cells since they are surrounded by an extracellular fluid which is, in itself, subjected to pH …

Lactacidosis occurring in cerebral ischemia or trauma is a major mechanism of cytotoxic
brain edema and brain damage. Respective effects of lactacidosis were currently analyzed …

The rat hippocampal slice preparation was used to study the combined effects of hypoxia
and lactic acidosis on neuronal function. Control slices were exposed to a standard hypoxic …

Excessive tissue lactic acidosis is considered to be detrimental to the central nervous system
(CNS) and may adversely affect recovery from anoxia, ischemia, trauma and epilepsy. Since …

The primary objective of this study was to compare the histopathological consequences of
complete versus incomplete ischemia under experimental conditions that limit lactate …