Cytokines in the pathogenesis of rheumatoid arthritis

IB McInnes, G Schett - Nature Reviews Immunology, 2007 - nature.com
Cytokines regulate a broad range of inflammatory processes that are implicated in the
pathogenesis of rheumatoid arthritis. In rheumatoid joints, it is well known that an imbalance …

Cytokines in rheumatoid arthritis—shaping the immunological landscape

IB McInnes, CD Buckley, JD Isaacs - Nature Reviews Rheumatology, 2016 - nature.com
Cytokine-mediated pathways are central to the pathogenesis of rheumatoid arthritis (RA).
The purpose of this short Opinion article is to briefly overview the roles of cytokine families in …

Anti-inflammatory and immune-regulatory cytokines in rheumatoid arthritis

Z Chen, A Bozec, A Ramming, G Schett - Nature Reviews …, 2019 - nature.com
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by a failure of
spontaneous resolution of inflammation. Although the pro-inflammatory cytokines and …

Role of pro-inflammatory cytokines in rheumatoid arthritis

FM Brennan, RN Maini, M Feldmann - Springer seminars in …, 1998 - Springer
Rheumatoid arthritis (RA) is well known to be a chronic autoimmune/inflammatory disease
which leads to progressive joint damage and destruction. Less well known is the fact that in …

Selected cytokine pathways in rheumatoid arthritis

M Noack, P Miossec - Seminars in immunopathology, 2017 - Springer
Rheumatoid arthritis (RA) is a chronic inflammatory disease leading to joint destruction.
Cytokines play a key role in its pathogenesis. They contribute to the induction and …

[HTML][HTML] Cell signalling in macrophages, the principal innate immune effector cells of rheumatoid arthritis

SK Drexler, PL Kong, J Wales, BM Foxwell - Arthritis research & therapy, 2008 - Springer
Rheumatoid arthritis is a multisystemic auto-inflammatory disease affecting up to 1% of the
population and leading to the destruction of the joints. Evidence exists for the involvement of …

Emerging cytokine targets in rheumatoid arthritis

DL Asquith, IB McInnes - Current opinion in rheumatology, 2007 - journals.lww.com
Novel cytokine activities are emerging on an ongoing basis. There remain difficulties in
ascribing the optimal regulatory hierarchy for given moieties on the basis of existing …

[HTML][HTML] Cytokine expression and cell activation in inflammatory arthritis

LB Ivashkiv - Advances in immunology, 1996 - Elsevier
Publisher Summary This chapter focuses upon the expression and role of cytokines in
rheumatoid arthritis (RA) that is one of the most intensively studied and best characterized …

[HTML][HTML] Cytokines in the pathogenesis of rheumatoid arthritis: new players and therapeutic targets

A Alunno, F Carubbi, R Giacomelli, R Gerli - BMC rheumatology, 2017 - Springer
In recent years, the landscape of pro-and anti-inflammatory cytokines has rapidly expanded
with the identification of new members proven to be involved at different extent in the …

Cytokines in rheumatoid arthritis: potential targets for pharmacological intervention

Z Szekanecz, AE Koch, SL Kunkel, RM Strieter - Drugs & aging, 1998 - Springer
The ingress of inflammatory leucocytes into the synovium is a crucial step in the
pathogenesis of rheumatoid arthritis (RA). Cytokines are mediators involved in the …