Synthesis of 68Ga-labeled biopolymer-based nanoparticle imaging agents for positron-emission tomography

Z Körhegyi, D Rózsa, I Hajdu, M Bodnár… - Anticancer …, 2019 - ar.iiarjournals.org
Aim: The purpose of this study was to develop a folate receptor-targeted 68Ga-labeled agent
for the detection of cancer cells in mouse models of ovarian cancer by dual positron …

Acid resistant zirconium phosphate for the long term application of 68Ge/68Ga generator system

JY Lee, CK Vyas, BR Kim, HJ Kim, MG Hur… - Applied Radiation and …, 2016 - Elsevier
Abstract The 68 Ge/68 Ga generator system is an excellent source for producing ready-to-
use Ga-68 in clinical Positron Emission Tomography (PET) applications. The column …

Detailed evaluation on the effect of metal ion impurities on complexation of generator eluted 68Ga with different bifunctional chelators

R Chakravarty, S Chakraborty, A Dash… - Nuclear Medicine and …, 2013 - Elsevier
INTRODUCTION: The introduction of 68Ga-based positron emission tomography (PET) to
clinical practice using 68Ge/68Ga generator represents a developmental milestone in the …

Folate decorated multifunctional biodegradable nanoparticles for gastric carcinoma active targeting theranostics

X Zhang, R Yan, Z Wei, D Yang, Z Hu… - International Journal …, 2022 - Taylor & Francis
Introduction Gastric cancer remains a major clinical issue and little progress has been made
in the treatment of gastric cancer patients during recent decades. Nanoparticles provide a …

[HTML][HTML] Arginine–glycine–aspartate (RGD)-targeted positron-labeled dendritic polylysine nanoprobe for tumor PET imaging

Q Fang, Y Xiao, R Zhang, J Yin, D Xie, X Wang - RSC advances, 2020 - pubs.rsc.org
This work investigated the optimization of the 68Ga radiolabeling of the dendritic polylysine-
1, 4, 7-triazacyclononane-1, 4, 7-triacetic acid conjugate (DGL-NOTA). Under pH= 4.0 …

[HTML][HTML] Clinically applicable cyclotron-produced gallium-68 gives high-yield radiolabeling of DOTA-based tracers

E Jussing, S Milton, E Samén, MM Moein, L Bylund… - Biomolecules, 2021 - mdpi.com
By using solid targets in medical cyclotrons, it is possible to produce large amounts of
68GaCl3. Purification of Ga3+ from metal ion impurities is a critical step, as these metals …

Nanoceria-PAN Composite-Based Advanced Sorbent Material: A Major Step Forward in the Field of Clinical-Grade 68Ge/68Ga Generator

R Chakravarty, R Shukla, R Ram… - … Applied Materials & …, 2010 - ACS Publications
The 68Ge/68Ga generator has high potential for clinical positron emission tomography
(PET) imaging. However, because of the unavailability of a suitable sorbent material, the …

Preparation and 68Ga-radiolabeling of porous zirconia nanoparticle platform for PET/CT-imaging guided drug delivery

A Polyak, LN Nagy, J Mihaly, S Görres… - … of pharmaceutical and …, 2017 - Elsevier
This paper describes the preparation of gallium-68 (68 Ga) isotope labeled porous zirconia
(ZrO 2) nanoparticle (NP) platform of nearly 100 nm diameter and its first pharmacokinetic …

Synthesis, characterization and biological evaluation of a well dispersed suspension of gallium-68-labeled magnetic nanosheets of graphene oxide for in vivo …

Y Fazaeli, R Rahighi, A Tayyebi, S Feizi - Radiochimica Acta, 2017 - degruyter.com
Graphene oxide (GO) nanosheets were hybridized with Fe3O4 nanoparticles (NPs) to form
magnetic GO (MGO) and were further labeled by [68Ga] GaCl3 as a potential drug delivery …

Chelators for 68Ga radiopharmaceuticals

SR Seelam, YS Lee, JM Jeong - … and Molecular Probes, 2016 - oldkmbase.medric.or.kr
Abstract 68Ga is a promising radionuclide for positron emission tomography (PET). It is a
generator-produced (68Ge/68Ga-generator) radionuclide with a half-life of 68 min. The …