Demyttenaere K, Haddad P. Compliance with antidepressant therapy and antidepressant
discontinuation symptoms. Acta Psychiatr Scand 2000: 101: 50–56.© Munksgaard 2000 …

Compliance is generally defined as the extent to which a patient adheres to a treatment
regimen and, specifically, takes medication as prescribed. While little research is available …

Background: In a previous study, we found that past medication use was associated with
medication adherence in patients prescribed atypical antipsychotics. Objective: The present …

Depressive disorders require long-term treatment with antidepressants, psychotherapy, or
both. The goal of antidepressant therapy is complete remission of symptoms and return to …

Objective: To identify predictors of nonadherence to continuation and maintenance
antidepressant medication among patients with remitted recurrent depression. Method: We …

Background: Treatment guidelines recommend antidepressant treatment be continued for at
least 6 months to ensure maximal improvement and to prevent relapse. Naturalistic studies …

Poor compliance with antidepressant medication is widespread in both primary care and
psychiatric practice, and is a major obstacle to the effective management of depression. It is …

To minimize the symptoms of antidepressant discontinuation, gradual tapering is necessary
for all serotonin reuptake inhibitors (SRIs) except fluoxetine, which has an extended half-life …

Objective: Patients with major depression discontinue taking their antidepressants for many
reasons. Although side effects are often cited as the reason for discontinuation, few …

Antidepressant discontinuation symptoms occur with all classes of antidepressant. A well-
described discontinuation syndrome occurs with the selective serotonin reuptake inhibitors …