Allergen specificity and endothelial transmigration of T cells in allergic contact dermatitis and atopic dermatitis are associated with the cutaneous lymphocyte antigen

LF Santamaria, MT Perez Soler, C Hauser… - International Archives of …, 1995 - karger.com
Recent investigations have indicated a role for antigen-specific T lymphocytes in the local
skin immunity. The cutaneous lymphocyte antigen (CLA) is supposed to represent a skin …

Nonspecific T-cell homing during inflammation in atopic dermatitis: expression of cutaneous lymphocyte-associated antigen and integrin αEβ7 on skin-infiltrating T …

IJM de Vries, EG Langeveld-Wildschut… - Journal of allergy and …, 1997 - Elsevier
Atopic dermatitis (AD) is a chronic skin disorder, characterized by infiltration of activated
memory CD4+ T cells into skin. A model to study the onset of allergic inflammation in a …

Circulating allergen-reactive T cells from patients with atopic dermatitis and allergic contact dermatitis express the skin-selective homing receptor, the cutaneous …

LF Santamaria Babi, LJ Picker… - The Journal of …, 1995 - rupress.org
The cutaneous lymphocyte-associated antigen (CLA) is the major T cell ligand for the
vascular adhesion molecule E-selectin, and it has been proposed to be involved in the …

Skin-homing T cells in human cutaneous allergic inflammation

LF Santamaria Babi, MT Perez Soler, C Hauser… - Immunologic …, 1995 - Springer
The cutaneous lymphocyte-associated antigen (CLA) is a carbohydrate epitope present on
memory/effector T cells that infiltrate inflamed skin. E-selectin is the ligand for CLA and is …

Expression of cutaneous lymphocyte‐associated antigen on human CD4+ and CD8+ Th2 cells

M Akdis, S Klunker, M Schliz, K Blaser… - European journal of …, 2000 - Wiley Online Library
The cutaneous lymphocyte‐associated antigen (CLA) represents the homing receptor
involved in selective migration of memory/effector T cells to the skin. Numerous reports …

Skin-homing T cells in cutaneous allergic inflammation

LF Santamaría-Babí - Allergy and Asthma in Modern Society: A …, 2006 - karger.com
The involvement of circulating cutaneous lymphocyte-associated (CLA)+ T cells in skin
allergy was initially described in atopic and contact dermatitis in a series of experiments …

Expansion and proliferation of skin-homing T cells in atopic dermatitis as assessed at the single cell level

T Jung, S Schulz, K Zachmann… - International archives of …, 2003 - karger.com
Background: Sensitization to aeroallergens is a frequent event in patients with atopic
dermatitis (AD). The role of allergen-specific T cells in the pathogenesis of AD is, however …

Skin-associated lymphocytes in the peripheral blood of patients with atopic dermatitis: signs of subset expansion and stimulation

MN Dworzak, G Fröschl, D Printz, C Fleischer… - Journal of allergy and …, 1999 - Elsevier
Background: Skin-associated T cells are defined by the cutaneous lymphocyte-associated
antigen (CLA). In atopic dermatitis (AD), CLA+ T cells harbor allergen-reactive memory cells …

Circulating CLA+ T cells in atopic dermatitis and their possible role as peripheral biomarkers

T Czarnowicki, LF Santamaria‐Babí… - Allergy, 2017 - Wiley Online Library
Cutaneous lymphocyte‐associated antigen (CLA+) T cells are specialized for skin homing
and represent the main T‐cell population in atopic dermatitis (AD) lesions. CLA+ is …

Migration of skin-homing T cells across cytokine-activated human endothelial cell layers involves interaction of the cutaneous lymphocyte-associated antigen (CLA) …

LF Santamaria Babi, R Moser… - … (Baltimore, Md.: 1950 …, 1995 - journals.aai.org
The cutaneous lymphocyte-associated Ag (CLA) is expressed by a subset of circulating
memory/effector T cells and by the vast majority of skin-infiltrating T cells. CLA is thought to …