Osteoarthritis of the knee is a leading cause of chronic disablity in the United States. It is a
heterogeneous condition that causes pathogenic changes that are presumably irreversible …

Methods: In this prospective randomised study, 172 patients who were diagnosed knee OA
and who received three consecutive intra-articular injections of HA weekly were included …

Objective: This article reviews the various pharmacological modalities for the treatment of
osteoarthritis (OA) of the knee, with a particular emphasis on the use of intra-articular (IA) …

Synovial fluid in patients may differ in molecular weight depending on the presence and
degree of osteoarthritis. Treatment is not directed at this relationship. Patients with …

The goal of this study was to assess the safety and efficacy of hyaluronan (HA) with/without
corticosteroid in patients with knee osteoarthritis (OA). In a 1-year, randomized, single-blind …

In a single-blind, randomized clinical trial, both the efficacy and safety of hyaluronic acid
(HA) were compared with that of mucopolysaccharide polysulfuric acid ester (MPA) in …

The objective of this study was to investigate mechanisms of action of intra-articular
hyaluronic acid in osteoarthritis (OA) of the knee. Twelve patients with bilateral knee OA and …

Although the predominant mechanism of intra-articular hyaluronan (hyaluronic acid)(HA)
and hylans for the treatment of pain associated with knee osteoarthritis (OA) is unknown, in …

Background: Although accepted as a conservative treatment option for knee osteoarthritis,
the debate about the effectiveness of intra-articular treatment with hyaluronic acid (HA) is still …

Hyaluronans are polysaccharide molecules that occur naturally in synovial fluid; they help to
create a viscous environment, cushion joints, and maintain normal function. The American …