Purpose The primary objective was to demonstrate the safety and effectiveness of
Monovisc™ in the relief of joint pain in patients with idiopathic knee OA compared to saline …

The effects of high molecular weight hyaluronan (HA) on cartilage degeneration were
investigated in a partial menisectomy model of osteoarthritis (OA) in the rabbit knee. This …

OBJECTIVE--To determine the safety and efficacy of intra-articular injections of hyaluronan
in the treatment of osteoarthritis of the knee. METHODS--A randomised double-blind …

Background: Hyaluronan, or hyaluronic acid (HA), is the major hydrodynamic nonprotein
component of joint synovial fluid (SF). Its unique viscoelastic properties confer remarkable …

Ann Rheum Dis: first published as 10.1136/ard. 57.11. 637 on 1 November 1998.
Downloaded from hyaluronan receptor CD44 abrogated tissue oedema and leucocyte …

This pilot study evaluated the safety and efficacy of intra-articular injection of hyaluronic acid
(HA) in patients with hip osteoarthritis (OA). Forty-four patients affected by monolateral or …

Objective To evaluate the efficacy and tolerability of a single intraarticular (IA) injection of
hyaluronic acid (HA) for the treatment of hip osteoarthritis (OA). Methods A multicenter …

Background: Osteoarthritis of the knee affects up to 10% of the elderly population. The
condition is frequently treated by intra-articular injection of hyaluronic acid. We performed a …

Objective To evaluate, in a pilot, open clinical trial on 40 patients with knee osteoarthritis, the
structural changes in the synovial membrane and cartilage following treatment with intra …

BACKGROUND: Intra-articular injection of hyaluronic acid (HA) is a well-documented
treatment for knee osteoarthritis (OA). One of the multifactorial mechanisms is that …