CEACAM1 in liver injury, metabolic and immune regulation

AK Horst, SM Najjar, C Wagener, G Tiegs - International journal of …, 2018 - mdpi.com
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a
transmembrane glycoprotein that is expressed on epithelial, endothelial and immune cells …

Reduced hepatic carcinoembryonic antigen-related cell adhesion molecule 1 level in obesity

G Heinrich, HT Muturi, K Rezaei, QY Al-Share… - Frontiers in …, 2017 - frontiersin.org
Impairment of insulin clearance is being increasingly recognized as a critical step in the
development of insulin resistance and metabolic disease. The carcinoembryonic antigen …

Forced hepatic overexpression of CEACAM1 curtails diet-induced insulin resistance

QY Al-Share, AM DeAngelis, SG Lester, TA Bowman… - Diabetes, 2015 - Am Diabetes Assoc
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) regulates insulin
sensitivity by promoting hepatic insulin clearance. Liver-specific inactivation or global null …

Role for hepatic CEACAM1 in regulating fatty acid metabolism along the adipocyte-hepatocyte axis [S]

L Russo, HE Ghadieh, SS Ghanem, QY Al-Share… - Journal of lipid …, 2016 - ASBMB
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) regulates insulin
sensitivity by promoting hepatic insulin clearance and mediating suppression of fatty acid …

The CEACAM1 expression is decreased in the liver of severely obese patients with or without diabetes

W Lee - Diagnostic pathology, 2011 - Springer
Background Type 2 diabetes is mainly caused by insulin resistance. The carcinoembryonic
antigen-related cell adhesion molecule 1 (CEACAM1) is an important candidate for causing …

Expression of newly identified secretory CEACAM1a isoforms in the intestinal epithelium

K Terahara, M Yoshida, F Taguchi, O Igarashi… - Biochemical and …, 2009 - Elsevier
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) regulates
intestinal immunological homeostasis. However, precise expression patterns of CEACAM1 …

Ceacam1 deletion causes vascular alterations in large vessels

SM Najjar, KJ Ledford, SL Abdallah… - American Journal …, 2013 - journals.physiology.org
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) promotes hepatic
insulin clearance and endothelial survival. However, its role in the morphology of …

Hepatic CEACAM1 expression indicates donor liver quality and prevents early transplantation injury

K Nakamura, S Kageyama, FM Kaldas… - The Journal of …, 2020 - Am Soc Clin Investig
Although CEACAM1 (CC1) glycoprotein resides at the interface of immune liver injury and
metabolic homeostasis, its role in orthotopic liver transplantation (OLT) remains elusive. We …

Loss of hepatic CEACAM1: a unifying mechanism linking insulin resistance to obesity and non-alcoholic fatty liver disease

G Heinrich, HE Ghadieh, SS Ghanem… - Frontiers in …, 2017 - frontiersin.org
The pathogenesis of human non-alcoholic fatty liver disease (NAFLD) remains unclear, in
particular in the context of its relationship to insulin resistance and visceral obesity. Work on …

Carcinoembryonic antigen-related cell adhesion molecule 2 controls energy balance and peripheral insulin action in mice

G Heinrich, S Ghosh, AM DeAngelis… - Gastroenterology, 2010 - Elsevier
BACKGROUND & AIMS: The carcinoembryonic antigen-related cell adhesion molecule 1
(CEACAM1) is a transmembrane glycoprotein with pleotropic functions, including clearance …