[HTML][HTML] Liver-specific reconstitution of CEACAM1 reverses the metabolic abnormalities caused by its global deletion in male mice
L Russo, HT Muturi, HE Ghadieh, SS Ghanem… - Diabetologia, 2017 - Springer
Aims/hypothesis The carcinoembryonic antigen-related cell adhesion molecule 1
(CEACAM1) promotes insulin clearance. Mice with global null mutation (Cc1−/−) or with liver …
(CEACAM1) promotes insulin clearance. Mice with global null mutation (Cc1−/−) or with liver …
[HTML][HTML] Hepatic CEACAM1 over-expression protects against diet-induced fibrosis and inflammation in white adipose tissue
SG Lester, L Russo, SS Ghanem, SS Khuder… - Frontiers in …, 2015 - frontiersin.org
CEACAM1 promotes insulin extraction, an event that occurs mainly in liver. Phenocopying
global Ceacam1 null mice (Cc1–/–), C57/BL6J mice fed a high-fat (HF) diet exhibited …
global Ceacam1 null mice (Cc1–/–), C57/BL6J mice fed a high-fat (HF) diet exhibited …
Mice with null mutation of Ceacam1 develop nonalcoholic steatohepatitis
S Ghosh, M Kaw, PR Patel, KJ Ledford… - Hepatic medicine …, 2010 - Taylor & Francis
Transgenic liver-specific inactivation of the carcinoembryonic antigen-related cell adhesion
molecule (CEACAM1) impairs hepatic insulin clearance and causes hyperinsulinemia …
molecule (CEACAM1) impairs hepatic insulin clearance and causes hyperinsulinemia …
CEACAMs: their role in physiology and pathophysiology
K Kuespert, S Pils, CR Hauck - Current opinion in cell biology, 2006 - Elsevier
Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) belong to a group
of mammalian immunoglobulin-related glycoproteins. They are involved in cell–cell …
of mammalian immunoglobulin-related glycoproteins. They are involved in cell–cell …
[HTML][HTML] CEACAM1 modulates epidermal growth factor receptor–mediated cell proliferation
GA Abou-Rjaily, SJ Lee, D May… - The Journal of …, 2004 - Am Soc Clin Investig
Phosphorylation of the cell adhesion protein CEACAM1 increases insulin sensitivity and
decreases insulin-dependent mitogenesis in vivo. Here we show that CEACAM1 is a …
decreases insulin-dependent mitogenesis in vivo. Here we show that CEACAM1 is a …
Hyperinsulinemia drives hepatic insulin resistance in male mice with liver-specific Ceacam1 deletion independently of lipolysis
HE Ghadieh, L Russo, HT Muturi, SS Ghanem… - Metabolism, 2019 - Elsevier
Background CEACAM1 regulates insulin sensitivity by promoting insulin clearance.
Accordingly, global C57BL/6J. Cc1−/− null mice display hyperinsulinemia due to impaired …
Accordingly, global C57BL/6J. Cc1−/− null mice display hyperinsulinemia due to impaired …
Host-related carcinoembryonic antigen cell adhesion molecule 1 promotes metastasis of colorectal cancer
A Arabzadeh, C Chan, AL Nouvion, V Breton… - Oncogene, 2013 - nature.com
Liver metastasis is the predominant cause of colorectal cancer (CRC)-related mortality in
developed countries. Carcinoembryonic antigen-related cell adhesion molecule 1 …
developed countries. Carcinoembryonic antigen-related cell adhesion molecule 1 …
CEACAM1 long cytoplasmic domain isoform is associated with invasion and recurrence of hepatocellular carcinoma
S Kiriyama, S Yokoyama, M Ueno, S Hayami… - Annals of surgical …, 2014 - Springer
Background The two isoforms of carcinoembryonic antigen-related cell adhesion molecule 1
(CEACAM1), 1 with a long cytoplasmic domain (CEACAM1-L) and 1 with a short (CEACAM1 …
(CEACAM1), 1 with a long cytoplasmic domain (CEACAM1-L) and 1 with a short (CEACAM1 …
[HTML][HTML] Loss of CEACAM1 is associated with poor prognosis and peritoneal dissemination of patients with gastric cancer
A Takeuchi, S Yokoyama, M Nakamori, M Nakamura… - Scientific Reports, 2019 - nature.com
CEACAM1 is associated with malignant potential of various cancers. The current study aims
to clarify the association between carcinoembryonic antigen-related cell adhesion molecule …
to clarify the association between carcinoembryonic antigen-related cell adhesion molecule …
[HTML][HTML] Liver-specific rescuing of CEACAM1 reverses endothelial and cardiovascular abnormalities in male mice with null deletion of Ceacam1 gene
L Russo, HT Muturi, HE Ghadieh, AM Wisniewski… - Molecular …, 2018 - Elsevier
Objective Mice with global null mutation of Ceacam1 (Cc1−/−), display impairment of insulin
clearance that causes hyperinsulinemia followed by insulin resistance, elevated hepatic de …
clearance that causes hyperinsulinemia followed by insulin resistance, elevated hepatic de …