Emerging role and targeting of carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) in human malignancies

B Johnson, D Mahadevan - Clinical cancer drugs, 2015 - ingentaconnect.com
Background: Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is a
member of the CEA family of cell adhesion proteins that belong to the immunoglobulin …

Genetic alterations and expression pattern of CEACAM1 in colorectal adenomas and cancers

JH Song, Z Cao, JH Yoon, SW Nam, SY Kim… - Pathology & Oncology …, 2011 - Springer
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is expressed on
epithelial cells throughout the intestinal tract and is a negative regulator of tumor cell growth …

The CEACAM1 N-terminal Ig domain mediates cis-and trans-binding and is essential for allosteric rearrangements of CEACAM1 microclusters

E Klaile, O Vorontsova, K Sigmundsson… - Journal of Cell …, 2009 - rupress.org
Cell adhesion molecules (CAMs) sense the extracellular microenvironment and transmit
signals to the intracellular compartment. In this investigation, we addressed the mechanism …

Clinical and experimental studies regarding the expression and diagnostic value of carcinoembryonic antigen-related cell adhesion molecule 1 in non-small-cell lung …

M Zhou, Y Du, Y Liu, Y Wang, Y He, C Yang, W Wang… - BMC cancer, 2013 - Springer
Background Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a
multifunctional Ig-like cell adhesion molecule that has a wide range of biological functions …

Mechanism of glucose intolerance in mice with dominant negative mutation of CEACAM1

SY Park, YR Cho, HJ Kim, EG Hong… - American Journal …, 2006 - journals.physiology.org
Mice with liver-specific overexpression of dominant negative phosphorylation-defective
S503A-CEACAM1 mutant (L-SACC1) developed chronic hyperinsulinemia resulting from …

CEACAM5 stimulates the progression of non-small-cell lung cancer by promoting cell proliferation and migration

X Zhang, X Han, P Zuo, X Zhang… - Journal of International …, 2020 - journals.sagepub.com
Objective To detect the expression of CEA-related cell adhesion molecule 5 (CEACAM5) in
non-small-cell lung cancer (NSCLC) and explore its function in the progression and …

CEACAM1: contact-dependent control of immunity

SD Gray-Owen, RS Blumberg - Nature Reviews Immunology, 2006 - nature.com
The carcinoembryonic-antigen-related cell-adhesion molecule (CEACAM) family of proteins
has been implicated in various intercellular-adhesion and intracellular-signalling-mediated …

The CEACAM1 transmembrane domain, but not the cytoplasmic domain, directs internalization of human pathogens via membrane microdomains

P Muenzner, V Bachmann, K Kuespert… - Cellular …, 2008 - Wiley Online Library
Several bacterial pathogens exploit carcinoembryonic antigen‐related cell adhesion
molecules (CEACAMs) to promote attachment and uptake into eukaryotic host cells. The …

Expression of CEACAM6 in resectable colorectal cancer: a factor of independent prognostic significance

P Jantscheff, L Terracciano, A Lowy… - Journal of clinical …, 2003 - ascopubs.org
Purpose: CEACAM6, CEACAM1, and human carcinoembryonic antigen (CEA) are
coexpressed in normal colorectal epithelia, but show deregulated expression in colorectal …

The expression of the CEACAM19 gene, a novel member of the CEA family, is associated with breast cancer progression

K Michaelidou, A Tzovaras… - International …, 2013 - spandidos-publications.com
Breast cancer (BC) continues to affect the lives of millions of women worldwide. Several
members of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) …