Cellular analysis of host cell infection by different developmental stages of Trypanosoma cruzi

L Florencio-Martínez, C Márquez-Dueñas… - Experimental …, 2010 - Elsevier
Trypanosoma cruzi is an obligate intracellular parasite that infects phagocytic and non-
phagocytic mammalian cells by a complex process that appears to involve several discrete …

Intracellular DNA replication and differentiation of Trypanosoma cruzi is asynchronous within individual host cells in vivo at all stages of infection

MC Taylor, A Ward, F Olmo… - PLoS neglected …, 2020 - journals.plos.org
Investigations into intracellular replication and differentiation of Trypanosoma cruzi within
the mammalian host have been restricted by limitations in our ability to detect parasitized …

Trypanosoma cruzi: single cell live imaging inside infected tissues

BL Ferreira, CM Orikaza, EM Cordero… - Cellular …, 2016 - Wiley Online Library
Although imaging the live Trypanosoma cruzi parasite is a routine technique in most
laboratories, identification of the parasite in infected tissues and organs has been hindered …

Exploiting Genetically Modified Dual-Reporter Strains to Monitor Experimental Trypanosoma cruzi Infections and Host-Parasite Interactions

MC Taylor, AF Francisco, S Jayawardhana… - T. cruzi Infection …, 2019 - Springer
Trypanosoma cruzi is the causative agent of Chagas disease, the most important parasitic
infection in Latin America. Despite a global research effort, there have been no significant …

Transient transfection and expression of foreign and endogenous genes in the intracellular stages of Trypanosoma cruzi

PK Padmanabhan, RB Polidoro, NS Barteneva… - Molecular and …, 2014 - Elsevier
The capacity for rapid localization of epitope-tagged or fluorescent fusion proteins in cells is
an important tool for biological discovery and functional analysis. For Trypanosoma cruzi …

Bioluminescent: fluorescent Trypanosoma cruzi reporter strains as tools for exploring Chagas disease pathogenesis and drug activity

MC Taylor, AI Ward, F Olmo… - Current …, 2021 - ingentaconnect.com
Chagas disease results from infection with the trypanosomatid parasite Trypanosoma cruzi.
Progress in developing new drugs has been hampered by the long term and complex nature …

A panel of phenotypically and genotypically diverse bioluminescent:fluorescent Trypanosoma cruzi strains as a resource for Chagas disease research

F Olmo, S Jayawardhana, AA Khan… - PLOS Neglected …, 2024 - journals.plos.org
Chagas disease is caused by Trypanosoma cruzi, a protozoan parasite that displays
considerable genetic diversity. Infections result in a range of pathological outcomes, and …

Establishment of larval zebrafish as an animal model to investigate Trypanosoma cruzi motility in vivo

V Akle, N Agudelo-Dueñas… - JoVE (Journal of …, 2017 - jove.com
Chagas disease is a parasitic infection caused by Trypanosoma cruzi, whose motility is not
only important for localization, but also for cellular binding and invasion. Current animal …

In Vivo Analysis of Trypanosoma cruzi Persistence Foci at Single-Cell Resolution

AI Ward, MD Lewis, AA Khan, CJ McCann… - Mbio, 2020 - Am Soc Microbiol
Infections with Trypanosoma cruzi are usually lifelong despite generating a strong adaptive
immune response. Identifying the sites of parasite persistence is therefore crucial to …

[HTML][HTML] In vivo imaging of trypanosomes for a better assessment of host–parasite relationships and drug efficacy

S Goyard, PL Dutra, P Deolindo, D Autheman… - Parasitology …, 2014 - Elsevier
The advances in microscopy combined to the invaluable progress carried by the utilization
of molecular, immunological or immunochemical markers and the implementation of more …