Triazoles have demonstrated significant efficacy in the treatment of fungal infections.
However, increasing drug resistance is a growing concern that negatively impacts their …

In our continuing efforts to discover novel triazoles with improved antifungal activity in vitro
and in vivo, a series of 41 novel compounds containing 1, 2, 3-triazole side chains were …

Over the past decades, a tremendous rise in invasive fungal infection diseases attributed to
the yeast Candida albicans in immunocompromised individuals poses a seriously …

A series of triazoles as miconazole analogues was designed, synthesized and characterized
by IR, NMR, MS and HRMS. All the newly prepared compounds were screened for their …

As a continuation study, 29 novel triazoles containing benzyloxy phenyl isoxazole side chain
were designed and synthesized based on our previous work. The majority of the compounds …

Today's research is focused on developing new safe drugs of clinical importance. Nitrogen-
containing heterocycles are abundant in the common of therapeutic scaffolds. Triazoles are …

Several five membered ring systems, eg, triazole, oxadiazole dithiazole and thiadiazole with
three heteroatoms at symmetrical or asymmetrical positions have been studied because of …

Azole antifungals, including fluconazole, have long been the first-line antifungal agents in
the fight against fungal infections. The emergence of drug-resistant strains and the …

In order to develop new triazole derivatives, we optimized the lead compound a6 by
structural modifications to obtain a series of (2R, 3R)-3-((1-substituted-1H-1, 2, 3-triazol-4-yl) …

The synthesis and extensive biological study of two new tridentates ligands based on
pyrazole and triazole are described. The antifungal activity against the budding yeast cells of …