We propose that stage D advanced heart failure be defined as the presence of progressive
and/or persistent severe signs and symptoms of heart failure despite optimized medical …

BACKGROUND: An improved understanding of the characteristics, treatment, and outcome
of patients with “Stage D” heart failure (HF) may improve patient outcomes. We conducted …

In broad terms,“advanced” heart failure describes a clinical syndrome characterized by
persistent or progressive symptoms and ventricular dysfunction despite guideline-directed …

Heart failure is a complex clinical syndrome resulting from impairment of ventricular filling or
ejection of blood associated with symptoms of dyspnea, fatigue, and peripheral and/or …

Stage D heart failure (HF) is associated with poor prognosis, yet little consensus exists on
the care of patients with HF approaching the end of life. Treatment options for end-stage HF …

This article updates the Heart Failure Association of the European Society of Cardiology
(ESC) 2007 classification of advanced heart failure and describes new diagnostic and …

Objectives: This study sought to estimate the rate of progression to Stage D heart failure (HF)
among outpatients with Stage C HF and to identify risk factors for progression. Background …

The public health impact and the need to intervene upon the worsening heart failure (HF)
epidemic are currently a matter of national interest. The greater than $39 billion annual cost …

Heart failure is a major public health problem, with a patient population of at least 10 million
in Europe and approximately 5 million in North America. 1–3 Because of its age-dependent …

Chronic heart failure (CHF) remains the only cardiovascular disease with an increasing
hospitalization burden and an ongoing drain on health care expenditures. The prevalence of …