LMP1-mediated glycolysis induces myeloid-derived suppressor cell expansion in nasopharyngeal carcinoma

TT Cai, SB Ye, YN Liu, J He, QY Chen, HQ Mai… - PLoS …, 2017 - journals.plos.org
Myeloid-derived suppressor cells (MDSCs) are expanded in tumor microenvironments,
including that of Epstein–Barr virus (EBV)-associated nasopharyngeal carcinoma (NPC) …

The role of EBV-encoded LMP1 in the NPC tumor microenvironment: from function to therapy

AKF Lo, CW Dawson, HL Lung, KL Wong… - Frontiers in …, 2021 - frontiersin.org
Nasopharyngeal carcinoma (NPC) is closely associated with Epstein-Barr virus (EBV)
infection. It is also characterized by heavy infiltration with non-malignant leucocytes. The …

Activation of the FGFR1 signalling pathway by the Epstein–Barr virus‐encoded LMP1 promotes aerobic glycolysis and transformation of human nasopharyngeal …

AKF Lo, CW Dawson, LS Young, CW Ko… - The Journal of …, 2015 - Wiley Online Library
Non‐keratinizing nasopharyngeal carcinoma (NPC) is closely associated with Epstein–Barr
virus (EBV) infection. The EBV‐encoded latent membrane protein 1 (LMP1) is believed to …

Epstein-Barr virus-encoded LMP2A induces an epithelial–mesenchymal transition and increases the number of side population stem-like cancer cells in …

QL Kong, LJ Hu, JY Cao, YJ Huang, LH Xu… - PLoS …, 2010 - journals.plos.org
It has been recently reported that a side population of cells in nasopharyngeal carcinoma
(NPC) displayed characteristics of stem-like cancer cells. However, the molecular …

Targeting Epstein–Barr virus oncoprotein LMP1-mediated glycolysis sensitizes nasopharyngeal carcinoma to radiation therapy

L Xiao, ZY Hu, X Dong, Z Tan, W Li, M Tang, L Chen… - Oncogene, 2014 - nature.com
Our goal in this work was to illustrate the Epstein-Barr virus (EBV)-modulated global
biochemical profile and provide a novel metabolism-related target to improve the therapeutic …

EBV latent membrane proteins promote hybrid epithelial-mesenchymal and extreme mesenchymal states of nasopharyngeal carcinoma cells for tumorigenicity

N Zhu, X Xu, Y Wang, MS Zeng, Y Yuan - PLoS Pathogens, 2021 - journals.plos.org
EBV-encoded LMPs are consistently detected in nasopharyngeal carcinoma (NPC). Recent
evidence suggests potential roles of LMP1 and LMP2A in Epithelial-to-mesenchymal …

Extracellular vesicle packaged LMP1-activated fibroblasts promote tumor progression via autophagy and stroma-tumor metabolism coupling

X Wu, Z Zhou, S Xu, C Liao, X Chen, B Li, J Peng, D Li… - Cancer letters, 2020 - Elsevier
Several reports have demonstrated that Epstein-Barr virus (EBV) encoded latent membrane
protein 1 (LMP1), which is transferred by extracellular vesicles (EVs) or exosomes, can …

Enhanced aerobic glycolysis of nasopharyngeal carcinoma cells by Epstein-Barr virus latent membrane protein 1

WW Sung, PR Chen, MH Liao, JW Lee - Experimental Cell Research, 2017 - Elsevier
Abstract Latent membrane protein 1 (LMP1) is a principal viral oncoprotein in Epstein-Barr
virus (EBV)-associated malignancies, including nasopharyngeal carcinoma (NPC), which …

LMP1‐positive extracellular vesicles promote radioresistance in nasopharyngeal carcinoma cells through P38 MAPK signaling

Z Zhang, X Yu, Z Zhou, B Li, J Peng, X Wu… - Cancer …, 2019 - Wiley Online Library
Radioresistance has been one of the impediments to effective nasopharyngeal carcinoma
(NPC) therapy in clinical settings. Epstein‐Barr virus (EBV) encoded latent membrane …

Cancer stem-like cell characteristics induced by EB virus-encoded LMP1 contribute to radioresistance in nasopharyngeal carcinoma by suppressing the p53-mediated …

CF Yang, LX Peng, TJ Huang, GD Yang, QQ Chu… - Cancer letters, 2014 - Elsevier
Emerging evidence confirms that cancer stem cells (CSCs) are responsible for the
chemoradioresistance of malignancies. EBV-encoded latent membrane protein 1 (LMP1) is …