Cryptococcus neoformans: Sex, morphogenesis, and virulence

Y Zhao, X Lin - Infection, Genetics and Evolution, 2021 - Elsevier
Cryptococcus neoformans is a dimorphic fungus that causes lethal meningoencephalitis
mainly in immunocompromised individuals. Different morphotypes enable this …

Profiling a killer, the development of Cryptococcus neoformans

L Kozubowski, J Heitman - FEMS microbiology reviews, 2012 - academic.oup.com
The ability of fungi to transition between unicellular and multicellular growth has a profound
impact on our health and the economy. Many important fungal pathogens of humans …

Life Cycle of Cryptococcus neoformans

Y Zhao, J Lin, Y Fan, X Lin - Annual review of microbiology, 2019 - annualreviews.org
Cryptococcus neoformans is a ubiquitous environmental fungus and an opportunistic
pathogen that causes fatal cryptococcal meningitis. Advances in genomics, genetics, and …

Cryptococcus neoformans Mating and Genetic Crosses

S Sun, SJ Priest, J Heitman - Current protocols in microbiology, 2019 - Wiley Online Library
The Cryptococcus pathogenic species complex is a group of opportunistic human fungal
pathogens that cause cryptococcal meningoencephalitis, an infection associated with …

Cryptococcal cell morphology affects host cell interactions and pathogenicity

LH Okagaki, AK Strain, JN Nielsen, C Charlier… - PLoS …, 2010 - journals.plos.org
Cryptococcus neoformans is a common life-threatening human fungal pathogen. The size of
cryptococcal cells is typically 5 to 10 µm. Cell enlargement was observed in vivo, producing …

New weapons in the Cryptococcus infection toolkit

LM Taylor-Smith, RC May - Current opinion in microbiology, 2016 - Elsevier
Highlights•Cryptococcus neoformans is a leading cause of mortality in immunocompromised
patients.•The Cryptococcus: phagocyte interaction profoundly impacts the outcome of …

The Link between Morphotype Transition and Virulence in Cryptococcus neoformans

L Wang, B Zhai, X Lin - PLoS pathogens, 2012 - journals.plos.org
Cryptococcus neoformans is a ubiquitous human fungal pathogen. This pathogen can
undergo morphotype transition between the yeast and the filamentous form and such …

Cryptococcus neoformans Hyperfilamentous Strain Is Hypervirulent in a Murine Model of Cryptococcal Meningoencephalitis

M Feretzaki, SE Hardison, FL Wormley Jr, J Heitman - PloS one, 2014 - journals.plos.org
Cryptococcus neoformans is a human fungal pathogen that causes lethal infections of the
lung and central nervous system in immunocompromised individuals. C. neoformans has a …

The morphotype heterogeneity in Cryptococcus neoformans

L Wang, X Lin - Current opinion in microbiology, 2015 - Elsevier
Highlights•Both host and environmental signals entail cryptococcal morphotype
heterogeneity.•Diverse morphotypes are coordinated with saprophytic and pathogenic …

Sexual Cycle of Cryptococcus neoformans var. grubii and Virulence of Congenic a and α Isolates

K Nielsen, GM Cox, P Wang, DL Toffaletti… - Infection and …, 2003 - Am Soc Microbiol
Cryptococcus neoformans is a human-pathogenic fungus that has evolved into three distinct
varieties that infect most prominently the central nervous system. A sexual cycle involving …