Single-dose HPV vaccine immunity: is there a role for non-neutralizing antibodies?

C Quang, AW Chung, IH Frazer, ZQ Toh… - Trends in …, 2022 - cell.com
A single dose of human papillomavirus (HPV) vaccine against HPV infection (prerequisite
for cervical cancer) appears to be as efficacious as two or three doses, despite inducing …

HPV vaccines: translating immunogenicity into efficacy

TB Turner, WK Huh - Human vaccines & immunotherapeutics, 2016 - Taylor & Francis
Currently available human papillomavirus (HPV) vaccines are very successful at preventing
persistent HPV infection and premalignant cervical lesions. In part due to the unique aspects …

HPV-immune response to infection and vaccination

M Stanley - Infectious agents and cancer, 2010 - Springer
HPV infection in the genital tract is common in young sexually active individuals, the majority
of whom clear the infection without overt clinical disease. However most of those who …

Cross-Reactivity, Epitope Spreading, and De Novo Immune Stimulation Are Possible Mechanisms of Cross-Protection of Nonvaccine Human Papillomavirus (HPV) …

M Nakagawa, W Greenfield… - Clinical and Vaccine …, 2015 - Am Soc Microbiol
Numerous versions of human papillomavirus (HPV) therapeutic vaccines designed to treat
individuals with established HPV infection, including those with cervical intraepithelial …

current knowledge on the role of HPV antibodies after natural infection and vaccination: implications for monitoring an HPV vaccination programme

M Mollers, JM Vossen, M Scherpenisse… - Journal of medical …, 2013 - Wiley Online Library
Abstract In 2006/2007, two vaccines were licensed against two of the most common HPV
types that cause about 70% of cervical cancers. Clinical trials show that vaccinated …

Prevention and treatment of papillomavirus-related cancers through immunization

IH Frazer, GR Leggatt… - Annual review of …, 2011 - annualreviews.org
Cervical and other anogenital cancers are initiated by infection with one of a small group of
human papillomaviruses (HPV). Virus-like particle-based vaccines have recently been …

HPV16/18 L1 VLP vaccine induces cross-neutralizing antibodies that may mediate cross-protection

TJ Kemp, A Hildesheim, M Safaeian, JG Dauner, Y Pan… - Vaccine, 2011 - Elsevier
Human papillomavirus (HPV) L1 VLP-based vaccines are protective against HPV vaccine-
related types; however, the correlates of protection have not been defined. We observed that …

Human papillomavirus-specific immune therapy: failure and hope

K Nieto, L Gissmann, L Schädlich - Antiviral therapy, 2010 - journals.sagepub.com
Recently, two prophylactic vaccines against the most significant oncogenic human
papillomaviruses (HPV; 16 and 18) became available that efficiently protect against …

HPV vaccine: an overview of immune response, clinical protection, and new approaches for the future

L Mariani, A Venuti - Journal of translational medicine, 2010 - Springer
Although long-term protection is a key-point in evaluating HPV-vaccine over time, there is
currently inadequate information on the duration of HPV vaccine-induced immunity and on …

Human papillomavirus vaccines–immune responses

M Stanley, LA Pinto, C Trimble - Vaccine, 2012 - Elsevier
Prophylactic human papillomavirus (HPV) virus-like particle (VLP) vaccines are highly
effective. The available evidence suggests that neutralising antibody is the mechanism of …