Relating global and local connectome changes to dementia and targeted gene expression in Alzheimer's disease

SSM Elsheikh, ER Chimusa… - Frontiers in human …, 2021 - frontiersin.org
Networks are present in many aspects of our lives, and networks in neuroscience have
recently gained much attention leading to novel representations of brain connectivity. The …

Genome-wide association study of brain connectivity changes for Alzheimer's disease

SSM Elsheikh, ER Chimusa, NJ Mulder, A Crimi - Scientific reports, 2020 - nature.com
Variations in the human genome have been found to be an essential factor that affects
susceptibility to Alzheimer's disease. Genome-wide association studies (GWAS) have …

Morphological connectivity differences in Alzheimer's disease correlate with gene transcription and cell‐type

H Yu, Y Ding, Y Wei, M Dyrba, D Wang… - Human brain …, 2023 - Wiley Online Library
Alzheimer's disease (AD) is one of the most prevalent forms of dementia in older individuals.
Convergent evidence suggests structural connectome abnormalities in specific brain …

Alzheimer's disease rewires gene coexpression networks coupling different brain regions

S Mitra, K Bp, S CR, NV Saikumar, P Philip… - npj Systems Biology …, 2024 - nature.com
Connectome studies have shown how Alzheimer's disease (AD) disrupts functional and
structural connectivity among brain regions. But the molecular basis of such disruptions is …

Transcriptomic profiles underlying functional brain networks at different stages of Alzheimer's disease: Genetics/genetic factors of Alzheimer's disease

M Yu, K Nho, SL Risacher, EJ Chumin… - Alzheimer's & …, 2020 - Wiley Online Library
Background Specific functional network connectivity patterns have been shown at different
stages along the Alzheimer's disease (AD) continuum, but the contribution of regional gene …

Comparison of brain connectomes by MRI and genomics and its implication in Alzheimer's disease

YJ Woo, P Roussos, V Haroutunian, P Katsel, S Gandy… - BMC medicine, 2020 - Springer
Background The human brain is complex and interconnected structurally. Brain connectome
change is associated with Alzheimer's disease (AD) and other neurodegenerative diseases …

The human connectome in Alzheimer disease—relationship to biomarkers and genetics

M Yu, O Sporns, AJ Saykin - Nature Reviews Neurology, 2021 - nature.com
The pathology of Alzheimer disease (AD) damages structural and functional brain networks,
resulting in cognitive impairment. The results of recent connectomics studies have now …

[HTML][HTML] Multimodal analysis of disease onset in Alzheimer's disease using Connectome, Molecular, and genetics data

S Oh, S Kim, J Lee, B Park, JH Won, H Park - NeuroImage: Clinical, 2024 - Elsevier
Alzheimer's disease (AD) and its related age at onset (AAO) are highly heterogeneous, due
to the inherent complexity of the disease. They are affected by multiple factors, such as …

Data-driven sequence of changes to anatomical brain connectivity in sporadic Alzheimer's disease

NP Oxtoby, S Garbarino, NC Firth, JD Warren… - Frontiers in …, 2017 - frontiersin.org
Model-based investigations of transneuronal spreading mechanisms in neurodegenerative
diseases relate the pattern of pathology severity to the brain's connectivity matrix, which …

Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer's disease

M Wang, P Roussos, A McKenzie, X Zhou, Y Kajiwara… - Genome medicine, 2016 - Springer
Background Alzheimer's disease (AD) is the most common form of dementia, characterized
by progressive cognitive impairment and neurodegeneration. However, despite extensive …