Relating global and local connectome changes to dementia and targeted gene expression in Alzheimer's disease
SSM Elsheikh, ER Chimusa… - Frontiers in human …, 2021 - frontiersin.org
Networks are present in many aspects of our lives, and networks in neuroscience have
recently gained much attention leading to novel representations of brain connectivity. The …
recently gained much attention leading to novel representations of brain connectivity. The …
Genome-wide association study of brain connectivity changes for Alzheimer's disease
SSM Elsheikh, ER Chimusa, NJ Mulder, A Crimi - Scientific reports, 2020 - nature.com
Variations in the human genome have been found to be an essential factor that affects
susceptibility to Alzheimer's disease. Genome-wide association studies (GWAS) have …
susceptibility to Alzheimer's disease. Genome-wide association studies (GWAS) have …
Morphological connectivity differences in Alzheimer's disease correlate with gene transcription and cell‐type
Alzheimer's disease (AD) is one of the most prevalent forms of dementia in older individuals.
Convergent evidence suggests structural connectome abnormalities in specific brain …
Convergent evidence suggests structural connectome abnormalities in specific brain …
Alzheimer's disease rewires gene coexpression networks coupling different brain regions
S Mitra, K Bp, S CR, NV Saikumar, P Philip… - npj Systems Biology …, 2024 - nature.com
Connectome studies have shown how Alzheimer's disease (AD) disrupts functional and
structural connectivity among brain regions. But the molecular basis of such disruptions is …
structural connectivity among brain regions. But the molecular basis of such disruptions is …
Transcriptomic profiles underlying functional brain networks at different stages of Alzheimer's disease: Genetics/genetic factors of Alzheimer's disease
Background Specific functional network connectivity patterns have been shown at different
stages along the Alzheimer's disease (AD) continuum, but the contribution of regional gene …
stages along the Alzheimer's disease (AD) continuum, but the contribution of regional gene …
Comparison of brain connectomes by MRI and genomics and its implication in Alzheimer's disease
Background The human brain is complex and interconnected structurally. Brain connectome
change is associated with Alzheimer's disease (AD) and other neurodegenerative diseases …
change is associated with Alzheimer's disease (AD) and other neurodegenerative diseases …
The human connectome in Alzheimer disease—relationship to biomarkers and genetics
The pathology of Alzheimer disease (AD) damages structural and functional brain networks,
resulting in cognitive impairment. The results of recent connectomics studies have now …
resulting in cognitive impairment. The results of recent connectomics studies have now …
[HTML][HTML] Multimodal analysis of disease onset in Alzheimer's disease using Connectome, Molecular, and genetics data
Alzheimer's disease (AD) and its related age at onset (AAO) are highly heterogeneous, due
to the inherent complexity of the disease. They are affected by multiple factors, such as …
to the inherent complexity of the disease. They are affected by multiple factors, such as …
Data-driven sequence of changes to anatomical brain connectivity in sporadic Alzheimer's disease
Model-based investigations of transneuronal spreading mechanisms in neurodegenerative
diseases relate the pattern of pathology severity to the brain's connectivity matrix, which …
diseases relate the pattern of pathology severity to the brain's connectivity matrix, which …
Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer's disease
Background Alzheimer's disease (AD) is the most common form of dementia, characterized
by progressive cognitive impairment and neurodegeneration. However, despite extensive …
by progressive cognitive impairment and neurodegeneration. However, despite extensive …
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