Antiprogestins form a new potential treatment modality for breast cancer and their mode of
action has been assessed in vitro on several breast cancer cell lines, in vivo in rats with …

Treatment with antiprogestins in a new treatment modality for breast cancer. Previously, in
rats with DMBA-induced mammary tumors we observed significant growth inhibitory effects …

Growth of the normal mammary gland involves proliferation, differentiation, programmed cell
death and remodelling of the basement membrane throughout the cyclic ovarian stimulation …

Background Reports about the effects of progestins on cell proliferation are contradictory.
We investigated the effect of progesterone, medroxyprogesterone acetate, megestrol …

Onapristone and other antiprogestins proved to possess a potent antitumor activity in
several hormone-dependent experimental breast cancer models. This activity is as strong or …

In addition to their antiprogestational activity, the antiprogestins RU486, ZK98. 299 and
ZK98. 734 possess varying antiglucocorticoid as well as androgen-like or antiandrogen-like …

In this report, we evaluate the effects of a 21-substituted-19-nor-progestin, CDB-4124, on 7,
12,-dimthylbenz (a) anthracene (DMBA)-induced mammary carcinogenesis in rats in …

In the transplantable MXT mammary tumor model of the mouse and in the DMBA-and MNU-
induced mammary tumor models of the rat, the progesterone antagonists ZK 98.299 and RU …

Progesterone antagonists (PAs)(antiprogestins) or progesterone receptor modulators
(PRMs) form an interesting category of new hormonal agents in the treatment of breast …

We have compared the effects of the progestin R5020 and the antiprogestin RU486 on the
growth of the MCF-7 and T47D breast cancer cell lines. Differences between the two …