Purpose: Medulloblastoma in children can be categorized into at least four molecular
subgroups, offering the potential for targeted therapeutic approaches to reduce treatment …

Background Recent progress in molecular analysis has advanced the understanding of
medulloblastoma (MB) and is anticipated to facilitate management of the disease. MB is …

Purpose Macrophage polarization plays an essential role in the tumor microenvironment of
brain tumors. However, the role of tumor-associated macrophages (TAMs) in …

Medulloblastoma, which is the most common malignant paediatric brain tumour, has a 70%
survival rate, but standard treatments often lead to devastating life-long side effects and …

Tumor-associated macrophages (TAMs) play an important role in tumor immunity and
comprise of subsets that have distinct phenotype, function, and ontology. Transcriptomic …

Medulloblastoma (MB) is the most common lethal malignant pediatric brain tumor. Adjuvant
immunotherapy for medulloblastoma has been proposed in both pre-clinical and clinical …

Knowledge on immune and stromal cells in medulloblastoma microenvironment is still
limited as previous work was frequently restricted by low sample size and the lack of …

Simple Summary The current treatment options for medulloblastoma, the most common
malignant childhood brain cancer, are associated with many negative side effects and …

Medulloblastoma (MB), the most common malignant pediatric brain tumor, is composed of at
least four molecular subgroups with distinct clinical characteristics. The sonic hedgehog …

Background Medulloblastoma (MB) is a heterogeneous disease in which neoplastic cells
and associated immune cells contribute to disease progression. We aimed to determine the …