The NOD-, LRR-and pyrin domain-containing protein 3 (NLRP3) inflammasome is a
cytoplasmic supramolecular complex that is activated in response to cellular perturbations …

Abstract NLRP3 (NOD-, LRR-and pyrin domain-containing protein 3) is an intracellular
sensor that detects a broad range of microbial motifs, endogenous danger signals and …

Inflammasomes are multiprotein complexes that assemble upon detection of danger signals
to activate the inflammatory enzyme caspase-1, trigger secretion of the highly …

ABSTRACT The NACHT, LRR and PYD domains-containing protein 3 (NLRP3)
inflammasome is a fascinating cellular machinery endowed with the capacity for rapid …

The NLRP3 inflammasome is a critical component of the innate immune system that
mediates caspase-1 activation and the secretion of proinflammatory cytokines IL-1β/IL-18 in …

Inflammasomes are multiprotein complexes that serve as a platform for caspase-1 activation
and interleukin-1β (IL-1β) maturation as well as pyroptosis. Though a number of …

As an important sensor in the innate immune system, NLRP3 detects exogenous pathogenic
invasions and endogenous cellular damage and responds by forming the NLRP3 …

Members of the nucleotide-binding domain and leucine-rich repeat (LRR)-containing (NLR)
family and the pyrin and HIN domain (PYHIN) family can form multiprotein complexes …

Inflammasomes are multi-protein signaling complexes that trigger the activation of
inflammatory caspases and the maturation of interleukin-1β. Among various inflammasome …

NLRP3 inflammasome is an intracellular protein complex that initiates cellular injury via
assembly of NLRP3, ASC and caspase-1 in response to microbial infection and sterile …