Limiting excess of fluid administration therefore seems appropriate, but it could be
counterbalanced by the thought potential harm of using vasoactive drugs when hypovolemia …

Sepsis can influence blood volume, its distribution, vascular tone, and cardiac function.
Persistent hypotension or the need for vasopressors after volume resuscitation is part of the …

Septic shock treatment remains a major challenge for intensive care units, despite the recent
prominent advances in both management and outcomes. Vasopressors serve as a …

Objective The optimal role of vasopressor therapy in septic shock is not known. We
hypothesized that the variability in the use of vasopressors to treat hypotension is associated …

As vascular tone depression is a hallmark of septic shock, administration of norepinephrine
is logical in this setting. In this article, we provide and develop the following arguments for an …

Background Vasopressors are commonly applied to restore and maintain blood pressure in
patients with sepsis. We aimed to evaluate the current practice and therapeutic goals …

Purpose Mortality rate for septic shock, despite advancements in knowledge and treatment,
remains high. Treatment includes administration of broad-spectrum antibiotics and …

Methods: We selected studies in adults with septic shock that compared the outcomes of
patients treated with vasopressin versus norepinephrine. Cochrane ROB 2.0 and the …

Background: Current guidelines recommend norepinephrine as the first-line vasopressor in
septic shock followed by addition of vasopressin to achieve a goal mean arterial pressure …

Background The effect of early vasopressin initiation on clinical outcomes in patients with
septic shock is uncertain. A systematic review and meta-analysis was performed to evaluate …